Graciela Krikun, PhD
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Obstetrics, Gynecology & Reproductive Sciences
College Street
New Haven, CT 06510-
United States
About
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Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
Biography
My current interests involved endometrial angiogenesis and hemostasis in both the non-pregnant and pregnant states. To this end we have recently found that the molecule "ICON" developed by Hu and Garen has been successful in eradicating endometriotic lesions in a mouse model of endometriosis. This occurs by destroying the aberrant vasculature supporting the disease. Lately I have become interested in reproductive immunology and am part of a program project directed by Dr. Gil Mor in which I study the maternal part of the innate immune system during implantation. Lastly, together with Dr. Hugh Taylor, I have learned and published several papers involving the endometrial stem cell population and the possible contributions of immune cells on the stem cell niche.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Mount Sinai School of Medicine (1984)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Graciela Krikun's published research.
Publications Timeline
A big-picture view of Graciela Krikun's research output by year.
Charles Lockwood, MD
Hugh Taylor, MD
Ramanaiah Mamillapalli, PhD
Seth Guller, PhD
Yuping Zhou
4Publications
26Citations
Publications
2024
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
1998
Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220.
Lockwood C, Krikun G, Hausknecht V, Papp C, Schatz F. Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220. Endocrinology 1998, 139: 4607-4613. DOI: 10.1210/en.139.11.4607.Peer-Reviewed Original ResearchCitationsConceptsSociety for Gynecologic InvestigationExpression of MMP-1Endometrial stromal cellsMMP-1 expressionGynecological investigationSteroid withdrawalImplanting trophoblastEndovascular invasionInhibitor expressionStromal cellsLocal hemorrhageMatrix metalloproteinasesMMP-1Enhanced expressionInhibition of MMP-1 expressionNational InstituteTranscriptional Regulation of the Tissue Factor Gene by Progestins in Human Endometrial Stromal Cells
Krikun G. Transcriptional Regulation of the Tissue Factor Gene by Progestins in Human Endometrial Stromal Cells. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 926-930. DOI: 10.1210/jc.83.3.926.Peer-Reviewed Original ResearchCitationsConcepts
1993
Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence
Guller S, Wozniak R, Krikun G, Burnham J, Kaplan P, Lockwood C. Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology 1993, 133: 1139-1146. DOI: 10.1210/en.133.3.1139.Peer-Reviewed Original ResearchConceptsTreatment of cytotrophoblastsIncreased levels of glucocorticoidsEffects of glucocorticoidsHuman term placentaLevels of glucocorticoidsPlacental functionExtracellular matrix protein synthesisHuman parturitionAssociated with parturitionTerm placentaMultiple extracellular matrix proteinsPlacental fibronectinDexamethasone treatmentCytotrophoblastMatrix protein synthesisDexamethasoneGlucocorticoidExtracellular matrix proteinsCell-associated materialImmunoprecipitation studiesOnfFNLevels of total proteinMessenger RNANorthern blottingOncofetal epitope
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Obstetrics, Gynecology & Reproductive Sciences
College Street
New Haven, CT 06510-
United States