2015
BMP signaling and microtubule organization regulate synaptic strength
Ball R, Peled E, Guerrero G, Isacoff E. BMP signaling and microtubule organization regulate synaptic strength. Neuroscience 2015, 291: 155-166. PMID: 25681521, PMCID: PMC4369397, DOI: 10.1016/j.neuroscience.2015.01.069.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAnimals, Genetically ModifiedBone Morphogenetic ProteinsCalciumDNA-Binding ProteinsDrosophilaDrosophila ProteinsFemaleFluorescent DyesImmunohistochemistryMicrotubule-Associated ProteinsMicrotubulesNeuromuscular JunctionPatch-Clamp TechniquesPresynaptic TerminalsReceptors, Cell SurfaceSynaptic TransmissionTranscription FactorsConceptsBone morphogenetic proteinMicrotubule organizationGlutamatergic Drosophila neuromuscular junctionDrosophila neuromuscular junctionLarval neuromuscular junctionDistal boutonsNeuromuscular junctionBMP pathwaySynaptic transmissionMorphogenetic proteinsSynaptic growthMolecular pathwaysSynaptic strengthMicrotubule systemHomeostatic regulationPathwayMicrotubulesSpastin mutationsPostsynaptic partnersMutationsTransmission strengthSelective mannerMuscle fibersProteinRegulation
2005
Heterogeneity in synaptic transmission along a Drosophila larval motor axon
Guerrero G, Reiff D, Agarwal G, Ball R, Borst A, Goodman C, Isacoff E. Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nature Neuroscience 2005, 8: 1188-1196. PMID: 16116446, PMCID: PMC1402256, DOI: 10.1038/nn1526.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsCalcium SignalingDiagnostic ImagingDrosophilaDrosophila ProteinsElectric StimulationEvoked PotentialsGene Expression Regulation, DevelopmentalImmunohistochemistryLarvaLuminescent ProteinsMembrane PotentialsMotor NeuronsMutagenesis, InsertionalNeuromuscular JunctionPatch-Clamp TechniquesSynaptic TransmissionConceptsNeuromuscular junctionGlutamate receptorsSynaptic transmissionAxonal branchesMotor axonsPostsynaptic terminalsIndividual boutonsBoutonsProximal connectionLarval neuromuscular junctionTransmission strengthLarval motor axonsDrosophila melanogaster larval neuromuscular junctionDistal boutonsDistal onesHigh Ca2Ca2InfluxAxonsReceptorsIn Vivo Performance of Genetically Encoded Indicators of Neural Activity in Flies
Reiff D, Ihring A, Guerrero G, Isacoff E, Joesch M, Nakai J, Borst A. In Vivo Performance of Genetically Encoded Indicators of Neural Activity in Flies. Journal Of Neuroscience 2005, 25: 4766-4778. PMID: 15888652, PMCID: PMC1464576, DOI: 10.1523/jneurosci.4900-04.2005.Peer-Reviewed Original ResearchAnimalsAnimals, Genetically ModifiedDose-Response Relationship, RadiationDrosophilaElectric StimulationFluorescence Resonance Energy TransferFluorescent DyesGene Expression RegulationGenetic EngineeringImmunohistochemistryIn Vitro TechniquesLarvaLuminescent ProteinsMicroscopy, ConfocalMolecular Probe TechniquesNeuromuscular JunctionNeuronsPresynaptic TerminalsReproducibility of ResultsTime Factors