2020
Limited-angle TOF-PET for intraoperative surgical applications: latest results
Sajedi S, Bläckberg L, Fakhri G, Sabet H. Limited-angle TOF-PET for intraoperative surgical applications: latest results. 2020, 00: 1-3. DOI: 10.1109/nss/mic42677.2020.9507853.Peer-Reviewed Original ResearchCoincidence time resolutionWater phantomTOF-PETSphere-to-background activity ratiosLesion phantomsPET detector moduleDepth of interactionPET detector technologySmall-area detectorsDiameter spheresTime-of-flight (TOFPhantom depthDetector modulesCrystal pixelsDetector technologyDetector headFlight (TOFTime resolutionPhantomReduce FNRDetectorConventional gammaLarger-areaPixel dimensionsAngle geometry
2019
Limited-Angle TOF-PET for Intraoperative Surgical Application
Sajedi S, Bläckberg L, Vittum B, Devabhaktuni A, Nejad M, Fakhri G, Choi H, Sabet H. Limited-Angle TOF-PET for Intraoperative Surgical Application. 2019, 00: 1-4. DOI: 10.1109/nss/mic42101.2019.9059690.Peer-Reviewed Original ResearchSentinel lymph nodeHigh-resolution positron emission tomographyTOF-PETNear-infraredDetector ringDetector blockIncreasing acquisition timeTorso phantomHot spheresBottom detectorPositron emission tomographyTime resolutionDetectorIdentification of sentinel lymph nodesAcquisition timeSentinel lymph node identificationReconstructed imagesAccurate identification of sentinel lymph nodesActivity concentrationsWhole-body positron emission tomographyComplete tumor removalFalse negative rateImage slicesImprove patient recoveryPatient bedTime of flight PET reconstruction using nonuniform update for regional recovery uniformity
Kim K, Kim D, Yang J, Fakhri G, Seo Y, Fessler J, Li Q. Time of flight PET reconstruction using nonuniform update for regional recovery uniformity. Medical Physics 2019, 46: 649-664. PMID: 30508255, PMCID: PMC6501218, DOI: 10.1002/mp.13321.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratio regionVariant step sizeSignal-to-noise ratioNesterov momentumOS-SQSUniform recoveryOS-EMStep sizeNon-TOF PETOrdered subsetsQuad-core CPUEarly stopping criterionGraphics processing unitsTime-of-flight PET reconstructionReconstruction methodPET reconstruction methodsNesterov's momentum methodImage qualityPET reconstructionTOF-PETOverall signal-to-noise ratioActive regionLow activity regionsComputer simulationsRecovery ratio
2015
Fast Estimation of Image Variance for Time-of-flight PET Reconstruction
Wang M, Hu G, Fakhri G, Zhang H, Li Q. Fast Estimation of Image Variance for Time-of-flight PET Reconstruction. 2015, 1-4. DOI: 10.1109/nssmic.2015.7582040.Peer-Reviewed Original ResearchImage varianceMaximum likelihood expectation maximizationTOF-PETAhstract-The useLikelihood expectation maximizationFast algorithmExpectation maximizationReduction of computation timeComputation timeImage qualityMonte Carlo simulationsUniform diskFast estimationAlgorithmAnalytical expressionsCarlo simulationsVariance predictionImagesPET imagingPositron emission tomographyPhantomMaximization
2014
Tof-Pet Ordered Subset Reconstruction Using Non-Uniform Separable Quadratic Surrogates Algorithm
Kim K, Ye J, Cheng L, Ying K, Fakhri G, Li Q. Tof-Pet Ordered Subset Reconstruction Using Non-Uniform Separable Quadratic Surrogates Algorithm. 2014, 963-966. DOI: 10.1109/isbi.2014.6868032.Peer-Reviewed Original ResearchSignal-to-noise ratioQuadratic surrogatesTOF-basedAlgorithm timeNoise ratioReconstruction algorithmReconstructed imagesAlgorithmConvergence rateImage qualityPET reconstructionTransmission reconstructionComputer simulationsTOF PET reconstructionTOF-PETEmission reconstructionAccurate imagingImagesSmall regionConvergenceComputerReconstructionNon-uniformityOSEM
2011
Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study
Surti S, Scheuermann J, Fakhri G, Daube-Witherspoon M, Lim R, Abi-Hatem N, Moussallem E, Benard F, Mankoff D, Karp J. Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study. Journal Of Nuclear Medicine 2011, 52: 712-719. PMID: 21498523, PMCID: PMC3104282, DOI: 10.2967/jnumed.110.086678.Peer-Reviewed Original ResearchConceptsLocalization receiver operating characteristicsTime-of-flight PETLong scan timesArea under the LROC curveScan timeFunction of scan timePatient sizeTime-of-flight (TOFLROC curveLow-uptake lesionsTOF imagesTOF kernelLesion detection taskTOF-PETWhole-body oncologyLesion detection performanceScanner fieldPhantom studyPatient body mass indexProbability of correct localizationLesion detectionSphere dataBody mass indexLarger patientsReceiver operating characteristicImprovement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET
Fakhri G, Surti S, Trott C, Scheuermann J, Karp J. Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET. Journal Of Nuclear Medicine 2011, 52: 347-353. PMID: 21321265, PMCID: PMC3088884, DOI: 10.2967/jnumed.110.080382.Peer-Reviewed Original ResearchConceptsTime-of-flight PETTime-of-flightTOF-PETTime-of-flight reconstructionBody mass indexList-mode dataNon-TOF PETObserver signal-to-noise ratioOrdered-subset expectation maximizationMass indexNon-TOFLesion detectionLesion detection performanceSpherical lesionsFunction of body mass indexSignal-to-noise ratioScan timePatient studiesLesion visibilityArtificial lesionsLiver lesionsPatientsLesionsLesion locationLow lesions