2010
Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism
El Fakhri G, Ouyang J. Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism. Methods In Molecular Biology 2010, 680: 237-246. PMID: 21153385, DOI: 10.1007/978-1-60761-901-7_16.Peer-Reviewed Original ResearchConceptsDopamine transporter functionBrain SPECTDifferential diagnosis of parkinsonismDifferential diagnosisDiagnosis of parkinsonismIdiopathic Parkinson's diseaseDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of idiopathic Parkinson's diseaseCorticobasal degenerationProgressive supranuclear palsyParkinson's diseaseMultiple system atrophyParkinsonSPECT protocol
2007
Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images
Kas A, Payoux P, Habert M, Malek Z, Cointepas Y, El Fakhri G, Chaumet-Riffaud P, Itti E, Remy P. Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images. Journal Of Nuclear Medicine 2007, 48: 1459-1467. PMID: 17704252, DOI: 10.2967/jnumed.106.038646.Peer-Reviewed Original ResearchConceptsStatistical parametric mappingDopamine transporterStatistical parametric mapping analysisIntraclass correlation coefficientStriatal (123)I-FP-CIT uptakeParkinson's diseaseStatistical parametric mapping approachEssential tremorBland-Altman graphical analysisStriatal volumeDopaminergic cell lossDAT imagingLow intraclass correlation coefficientsParametric mappingSpatial normalizationNo significant differencePD patientsCustomized templateIntergroup analysisCell lossSpatial normalization procedureResults of groupSPM normalizationSignificant differenceSPECTComparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects
Trott C, Fakhri G. Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects. 2007, 5: 3616-3620. DOI: 10.1109/nssmic.2007.4436906.Peer-Reviewed Original ResearchDopamine transporterEarly stages of PDDual-isotope SPECTStages of PDSequential SPECTDisease stageSimultaneous dual-isotope studyStriatal sizeBrain functionImprove patient managementEstimation taskDual-isotope studiesBrain PETDopamineClinical symptomsParkinson's diseasePatient managementSPECT imagesSpecific bindingMotor functionSPECTBrainEarly detectionActivity concentrationsIdentical physiological conditions
2005
Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy
El Fakhri G, Habert M, Maksud P, Kas A, Malek Z, Kijewski M, Lacomblez L. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy. European Journal Of Nuclear Medicine And Molecular Imaging 2005, 33: 87-92. PMID: 16180033, DOI: 10.1007/s00259-005-1920-y.Peer-Reviewed Original ResearchConceptsMultiple system atrophyIdiopathic Parkinson's diseaseDopamine transporterDopamine transporter binding potentialNormal controlsVoxel-based statistical parametric mappingAsymmetry indexMultiple system atrophy patientsCompared to normal controlsCaudate nucleusDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of parkinsonian syndromesPatient-specific attenuationDiagnosis of idiopathic Parkinson's diseaseBinding potentialIdiopathic Parkinson's disease patientsDual-isotope SPECTVariable collimator responseParkinson's diseaseDifferential diagnosisDecreased perfusionStatistical parametric mappingPurposeThe purposeSystem atrophyParkinsonian syndromes