2022
Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging
Sun T, Wang Z, Wu Y, Gu F, Li X, Bai Y, Shen C, Hu Z, Liang D, Liu X, Zheng H, Yang Y, El Fakhri G, Zhou Y, Wang M. Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 2994-3004. PMID: 35567627, PMCID: PMC9106794, DOI: 10.1007/s00259-022-05832-7.Peer-Reviewed Original ResearchConceptsPET imagingNormal control databaseTotal-body imagingWhole-body PET imagingNon-invasive modalitySUV measurementsGastrointestinal bleedingMetabolic abnormitiesSystem abnormalitiesTotal bodyLung cancerHealthy subjectsMetabolic dysfunctionFocal lesionsCOVID-19 diseaseGlucose metabolismControl databaseSUV imagesPatientsAbnormal networkBiological mechanismsDiseasePETMetabolic connectivity
2017
Robust Correlation between Immediate Post Radio-Chemotherapy FDG PET Response and Clinical Outcome and Impact of Salvage Radiation for Partial Metabolic Responders in Locally Advanced Non–Small Cell Lung Cancer
Choi N, Ackman J, Lim R, Gainor J, Sharp G, Fakhri G, Niemierko A. Robust Correlation between Immediate Post Radio-Chemotherapy FDG PET Response and Clinical Outcome and Impact of Salvage Radiation for Partial Metabolic Responders in Locally Advanced Non–Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e447. DOI: 10.1016/j.ijrobp.2017.06.1673.Peer-Reviewed Original ResearchSynthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib
Collier T, Normandin M, Stephenson N, Livni E, Liang S, Wooten D, Esfahani S, Stabin M, Mahmood U, Chen J, Wang W, Maresca K, Waterhouse R, El Fakhri G, Richardson P, Vasdev N. Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib. Nature Communications 2017, 8: 15761. PMID: 28594000, PMCID: PMC5472746, DOI: 10.1038/ncomms15761.Peer-Reviewed Original ResearchMeSH KeywordsAminopyridinesAnaplastic Lymphoma KinaseAnimalsCarbon RadioisotopesChemistry Techniques, SyntheticContrast MediaFluorine RadioisotopesHumansIsotope LabelingLactamsLactams, MacrocyclicMacaca mulattaMaleMicePositron-Emission TomographyProtein-Tyrosine KinasesProto-Oncogene ProteinsPyrazolesTissue DistributionXenograft Model Antitumor AssaysConceptsAnaplastic lymphoma kinasePositron emission tomographyPositron emission tomography imagingC-ros oncogene 1Non-small cell lung cancerCell lung cancerBrain tumor lesionsOptimal therapeutic outcomesLung cancer patientsBlood-brain barrierPF-06463922Clinical trial investigatorsTumor uptakeLung cancerSmall molecule inhibitorsCancer patientsTherapeutic outcomesLorlatinibEmission tomographyDosimetry assessmentNon-human primatesTrial investigatorsBrain permeabilityEarly goalRadiolabeling strategies
2015
Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e438-e439. DOI: 10.1016/j.ijrobp.2015.07.1664.Peer-Reviewed Original ResearchSVM Based Lung Cancer Diagnosis Using Multiple Image Features in PET/CT
Guo N, Yen R, Fakhri G, Li Q. SVM Based Lung Cancer Diagnosis Using Multiple Image Features in PET/CT. 2015, 1-4. DOI: 10.1109/nssmic.2015.7582234.Peer-Reviewed Original ResearchIntra-tumor heterogeneityLung cancer diagnosisF-FLTCT textureStage malignancyLung cancerStaging of lung cancerCT texture featuresAdvanced stage malignanciesEarly stage malignancyImprove tumor stagingCancer diagnosisImage featuresPET/CT scansPET/CT imagingTumor stageTumor heterogeneityCancer stageDiagnostic accuracyPatient groupClinical valuePET/CTGold standardLung nodulesPET imaging