2023
Locus coeruleus metabolic changes as a predictor of tau accumulation and cognitive decline
Koops E, Dutta J, Becker A, Van Egroo M, Riphagen J, Hanseeuw B, Sperling R, Fakhri G, Johnson K, Jacobs H. Locus coeruleus metabolic changes as a predictor of tau accumulation and cognitive decline. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073715.Peer-Reviewed Original ResearchBeta-amyloidTau pathologyAlzheimer's diseaseNeuropathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseP-tauBeta-amyloid levelsP-tau accumulationMetabolic turnoverAccumulation of p-tauMarkers of AD progressionTau formationLocus coeruleusAD pathological changesTau accumulationNeuropathological hallmarksAD progressionPhosphorylated-tauPositron emission tomographyLate stageLociPairwise analysisMetabolismPair-wise differencesFDG-PET signal
2022
High-Resolution Structural Brainstem Nuclei: Locus Coeruleus Integrity as Potential Biomarker of Alzheimer’s Disease-Related Phenotypes
Jacobs H, Becker J, Kwong K, Engels-Dominguez N, Prokopiou P, Papp K, Properzi M, Hamptom O, Uquillas F, Sanchez J, Rentz D, Fakhri G, Normandin M, Price J, Bennett D, Sperling R, Johnson K. High-Resolution Structural Brainstem Nuclei: Locus Coeruleus Integrity as Potential Biomarker of Alzheimer’s Disease-Related Phenotypes. Biological Psychiatry 2022, 91: s31. DOI: 10.1016/j.biopsych.2022.02.095.Peer-Reviewed Original Research