2019
Renal clearable nanochelators for iron overload therapy
Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo M, El Fakhri G, Hutchens M, Choi H, Kim J. Renal clearable nanochelators for iron overload therapy. Nature Communications 2019, 10: 5134. PMID: 31723130, PMCID: PMC6853917, DOI: 10.1038/s41467-019-13143-z.Peer-Reviewed Original ResearchConceptsIron overloadIntravenous injectionDaily sc injectionsUrinary iron excretionSecondary iron overloadIron-overloaded miceAdverse side effectsIron chelatorsIron overload disordersGastrointestinal bleedingSC injectionIron excretionLiver fibrosisSide effectsKidney damageKidney failureIron overload therapyIron levelsToxic ironPharmacokinetic propertiesDeferoxamineNanochelatorKidneyExcretionInjection
2015
Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models
Wilks M, Normandin M, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten D, Fakhri G, Josephson L. Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjugate Chemistry 2015, 26: 1061-1069. PMID: 25971846, PMCID: PMC5378316, DOI: 10.1021/acs.bioconjchem.5b00213.Peer-Reviewed Original Research