2022
A multi-pronged investigation of option generation using depression, PET and modafinil
Ang Y, Cusin C, Petibon Y, Dillon D, Breiger M, Belleau E, Normandin M, Schroder H, Boyden S, Hayden E, Levine M, Jahan A, Meyer A, Kang M, Brunner D, Gelda S, Hooker J, Fakhri G, Fava M, Pizzagalli D. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain 2022, 145: 1854-1865. PMID: 35150243, PMCID: PMC9166534, DOI: 10.1093/brain/awab429.Peer-Reviewed Original ResearchConceptsD2/D3 receptor availabilitySelf-generated optionsDepressive disorderDepressed individualsReceptor availabilityDopamine D2/D3 receptor availabilityNon-depressed adultsEffects of modafinilPutamen of patientsAssociated with uniquenessOption generationD2/D3 receptorsDopaminergic activityClinical depressionBinding potentialModafinilHealthy participantsPutamenPlacebo-controlledSamples of healthy peopleDouble-blindDisordersSelf-generationHealthy controlsDopamine
2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2014
Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: preliminary PET imaging study with [3-11C]-(+)PHNO
Shoup T, McCauley J, Lee D, Chen R, Normandin M, Bonab A, Fakhri G, Vasdev N. Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: preliminary PET imaging study with [3-11C]-(+)PHNO. Tetrahedron Letters 2014, 55: 682-685. DOI: 10.1016/j.tetlet.2013.11.113.Peer-Reviewed Original ResearchPositron emission tomography imaging studiesSupercritical fluid chromatographyPositron emission tomographyFluid chromatographyImaging studiesAgonist radiopharmaceuticalsDopamine receptorsEnantiomeric resolutionDopamineCarbon-11Emission tomographyAdipose tissueBrown adipose tissueIn vivoBrown fatSynthesis
2007
Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects
Trott C, Fakhri G. Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects. 2007, 5: 3616-3620. DOI: 10.1109/nssmic.2007.4436906.Peer-Reviewed Original ResearchDopamine transporterEarly stages of PDDual-isotope SPECTStages of PDSequential SPECTDisease stageSimultaneous dual-isotope studyStriatal sizeBrain functionImprove patient managementEstimation taskDual-isotope studiesBrain PETDopamineClinical symptomsParkinson's diseasePatient managementSPECT imagesSpecific bindingMotor functionSPECTBrainEarly detectionActivity concentrationsIdentical physiological conditions