Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas
Panse G, Chrisinger JS, Leung CH, Ingram DR, Khan S, Wani K, Lin H, Lazar AJ, Wang W. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology 2017, 72: 239-247. PMID: 28796347, DOI: 10.1111/his.13337.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCo-Repressor ProteinsDisease-Free SurvivalFemaleHemangiosarcomaHumansKaplan-Meier EstimateMaleMiddle AgedMolecular ChaperonesNuclear ProteinsPrognosisReceptors, NotchX-linked Nuclear ProteinYoung AdultConceptsNotch2 expressionWorse disease-specific survivalWorse event-free survivalDisease-specific survivalEvent-free survivalMalignant vascular tumorsPoor clinical outcomeATRX lossCase of angiosarcomaDeep soft tissuesPathogenesis of angiosarcomaTumor suppressive roleProtein 6 expressionNotch receptor expressionMental retardation syndrome XMultiple genetic alterationsSite of originInhibition of NotchAdvanced diseaseCutaneous sitesClinical outcomesPrognostic significanceClinicopathological analysisSyndrome XVascular tumors