Gang-Qing Yao, MD
Senior Research ScientistDownloadHi-Res Photo
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Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
Titles
Senior Research Scientist
Appointments
Endocrinology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Chinese Academy of Medical Sciences (1987)
- MM
- Shandong Academy of Medical Sciences, Virology (1984)
- MD
- Gannan Medical University (1981)
- Fellow
- Chinese Academy of Medical Sciences
Research
Overview
Medical Research Interests
Bone and Bones
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gang-Qing Yao's published research.
Publications Timeline
A big-picture view of Gang-Qing Yao's research output by year.
Research Interests
Research topics Gang-Qing Yao is interested in exploring.
Karl Insogna, MD, FACP
Meiling Zhu
Steven Tommasini, PhD
Angeliki Louvi, PhD
Tamas Horvath, DVM, PhD
Thomas Carpenter, MD
29Publications
717Citations
Bone and Bones
Publications
2024
Corrigendum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Molecul. Cellul. Endocrinol. 595 (2025) 112412]
Yao G, Zhu M, Insogna K. Corrigendum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Molecul. Cellul. Endocrinol. 595 (2025) 112412]. Molecular And Cellular Endocrinology 2024, 112429. PMID: 39616004, DOI: 10.1016/j.mce.2024.112429.Peer-Reviewed Original ResearchPTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein
Yao G, Zhu M, Insogna K. PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein. Molecular And Cellular Endocrinology 2024, 595: 112412. PMID: 39536935, DOI: 10.1016/j.mce.2024.112412.Peer-Reviewed Original ResearchConceptsReceptor activator of nuclear factor kappa-B ligandReceptor activator of nuclear factor kappa-B ligand mRNAAU-rich elementsParathyroid hormone treatmentParathyroid hormoneMRNA stabilityRegulation of mRNA stabilityAU-rich element-binding proteinBinding to AU-rich elementsActivation of transcriptionInhibition of cellular transcriptionRegulate mRNA stabilityCells treated with vehicleSplicing regulatory proteinKH-type splicing regulatory proteinNuclear factor kappa-B ligandAu-richElement-binding proteinTNF family membersCellular transcriptionAssociated with increased phosphorylationPTH exposureRegulatory proteinsBinding proteinCells pre-treated
2023
Altered Expression of Several Molecular Mediators of Cerebrospinal Fluid Production in Hyp Mice
Kaplan J, Tommasini S, Yao G, Zhu M, Nishimura S, Ghazarian S, Louvi A, Insogna K. Altered Expression of Several Molecular Mediators of Cerebrospinal Fluid Production in Hyp Mice. Journal Of The Endocrine Society 2023, 7: bvad022. PMID: 36819458, PMCID: PMC9936957, DOI: 10.1210/jendso/bvad022.Peer-Reviewed Original ResearchCitationsAltmetric
2021
An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone
Walker JM, Yao GQ, Siu E, Zhu M, Sun BH, Simpson C, Insogna KL. An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone. Endocrinology 2021, 162: bqab042. PMID: 33640975, PMCID: PMC8095390, DOI: 10.1210/endocr/bqab042.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSphk2-/- miceParathyroid hormoneAnabolic responseFemoral trabecular BV/TVLower spinal bone mineral densityTrabecular BV/TVSpinal bone mineral densityDaily parathyroid hormoneFemoral bone volumeSuppression of sclerostinEnd of treatmentNormal bone massBone mineral densityNormal bone remodelingRole of SphK1BV/TVFemale control animalsSphingosine kinase 2Sphingosine kinaseControl miceLow BMDAnabolic effectsBone massMineral densityControl animals
2020
Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene
Yao GQ, Zhu M, Walker J, Insogna K. Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene. Calcified Tissue International 2020, 107: 52-59. PMID: 32246175, PMCID: PMC7274855, DOI: 10.1007/s00223-020-00685-4.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsColony stimulating factor 1Sphingosine kinase 1Bp fragmentSPHK1 promoterBp sequenceSphK1 geneDNA cis elementsProtein binding regionsSPHK1 gene expressionBp DNA fragmentStimulating factor 1Dual-luciferase reporterPutative DNATranscriptional activationTranscription factorsNuclear proteinsDNA sequencesCis elementsDNA bindingGene expressionPromoter activityDNA fragmentsKinase 1EMSAsProtein binding
2017
Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice
Yao GQ, Troiano N, Simpson CA, Insogna KL. Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice. Bone Research 2017, 5: 17022. PMID: 29152381, PMCID: PMC5684603, DOI: 10.1038/boneres.2017.22.Peer-Reviewed Original ResearchCitationsConceptsBone mineral densityEstrogen-deficiency bone lossBone lossO miceTotal bone mineral densityWild-type female miceDual-energy X-ray absorptiometryX-ray absorptiometrySham-OVXReverse transcription-PCRFemale miceMineral densityWT controlsOVXSelective deletionMiceTranscription-PCRSignificant differencesCSF1Bone tissueMicro-CTSkeletal tissuesTissueNon-redundant functionsAnimals
2016
An Unusual Case of Rickets and How Whole Exome Sequencing Helped to Correct a Diagnosis
Peter P, Brownstein C, Yao G, Olear E, Simpson C, Agrawal P, Carpenter T, Insogna K. An Unusual Case of Rickets and How Whole Exome Sequencing Helped to Correct a Diagnosis. AACE Clinical Case Reports 2016, 2: ee278-ee283. DOI: 10.4158/ep15944.cr.Peer-Reviewed Original ResearchCitationsConceptsWhole-exome sequencingForms of ricketsExome sequencingGrowth factor 23Classic clinical featuresClinical suspicionClinical featuresClinical presentationFactor 23Parathyroid hormoneDihydroxyvitamin D3Correct diagnosisMistaken diagnosisUnusual caseNutritional deficienciesRicketsPatientsDiagnosisDiseaseHypophosphatemiaGenetic defectsCompound heterozygotesCYP27B1Gene sequencing technologyXLH
2015
AgRP Neurons Regulate Bone Mass
Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. AgRP Neurons Regulate Bone Mass. Cell Reports 2015, 13: 8-14. PMID: 26411686, PMCID: PMC5868421, DOI: 10.1016/j.celrep.2015.08.070.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAgouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusBone DensityBone Diseases, MetabolicFemurGene Expression RegulationHomeostasisHypothalamusIon ChannelsLeptinMaleMiceMice, KnockoutMitochondrial ProteinsNeuronsNorepinephrinePhenotypePropranololReceptors, Adrenergic, betaReceptors, LeptinSignal TransductionSirtuin 1TibiaUncoupling Protein 2ConceptsAgRP neuronsCell-autonomous deletionSignificant regulatory roleAgRP neuronal functionBone massLeptin receptor deletionSkeletal bone metabolismTransgenic animalsRegulatory roleGene deletionBone homeostasisDeletionNeuronal functionPostnatal deletionSympathetic toneReceptor deletionArcuate nucleusLeptin actionBone metabolismSkeletal metabolismMultiple linesNeuronsMiceMetabolismCircuit integrity
2014
The Transcription Factor T-box 3 Regulates Colony-stimulating Factor 1-dependent Jun Dimerization Protein 2 Expression and Plays an Important Role in Osteoclastogenesis*
Yao C, Yao GQ, Sun BH, Zhang C, Tommasini SM, Insogna K. The Transcription Factor T-box 3 Regulates Colony-stimulating Factor 1-dependent Jun Dimerization Protein 2 Expression and Plays an Important Role in Osteoclastogenesis*. Journal Of Biological Chemistry 2014, 289: 6775-6790. PMID: 24394418, PMCID: PMC3945339, DOI: 10.1074/jbc.m113.499210.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2013
Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element
Thomas C, Yao G, O'Brien K, Kerstetter J, Insogna K. Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element. The FASEB Journal 2013, 27: lb284-lb284. DOI: 10.1096/fasebj.27.1_supplement.lb284.Peer-Reviewed Original ResearchConceptsIntestinal iron absorptionIron absorptionDietary proteinProtein dietMRNA expressionWhole-body iron homeostasisDuodenum of ratsDMT1 mRNA expressionBody iron homeostasisGenetic absenceExperimental animalsLevel of expressionResponsive elementBrush border membraneRatsIron-responsive elementRecent dataDietCritical regulatorIron homeostasisBorder membraneSignificant changesExpressionIron importerAnimals
Academic Achievements & Community Involvement
activity PTH-dependent stabilization of RANKL mRNA is associated with a selective increase in binding of phosphorylated KSRP, an AU-rich element binding-protein, to RANKL transcripts
Poster PresentationASBMR Annual MeetingDetails10/13/2023 - PresentVancouver, BC, CanadaCollaboratorsactivity Parathyroid Hormone does not change the expression of adenylate-uridylate-rich element binding proteins as part of the mechanism by which it stabilizes Receptor Activator of NF Kappa B Ligand Transcripts
Poster PresentationASBMR Annual MeetingDetails09/07/2022 - PresentAustin, TX, United StatesCollaboratorsactivity The anabolic actions of PTH are mediated in part through a Colony Stimulating Factor 1-sphingosine-1-phosphate paracrine loop
Poster PresentationASBMR Annual MeetingDetails10/10/2018 - PresentAtlanta, GA, United StatesCollaboratorsactivity The anabolic actions of PTH are mediated in part through a Colony Stimulating Factor 1-sphingosine-1-phosphate paracrine loop
Poster PresentationASBMR Annual MeetingDetails10/11/2016 - PresentAtlanta, GA, United StatesCollaboratorsactivity Selective deletion of the Soluble Colony Stimulating Factor 1 isoform in vivo eliminates estrogen-deficiency bone loss in mice
Oral PresentationASBMR Annual MeetingDetails10/11/2012 - PresentMinneapolis, MN, United StatesCollaborators- Gang-Qing Yao, MD
- Sun, B-H
- Wu, J
- Karl Insogna, MD, FACP
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Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States