2023
Generation of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencing
2022
Advanced in vitro models: Microglia in action
Cakir B, Kiral F, Park I. Advanced in vitro models: Microglia in action. Neuron 2022, 110: 3444-3457. PMID: 36327894, DOI: 10.1016/j.neuron.2022.10.004.Peer-Reviewed Original Research
2018
Rab GTPases and Membrane Trafficking in Neurodegeneration
Kiral F, Kohrs F, Jin E, Hiesinger P. Rab GTPases and Membrane Trafficking in Neurodegeneration. Current Biology 2018, 28: r471-r486. PMID: 29689231, PMCID: PMC5965285, DOI: 10.1016/j.cub.2018.02.010.Peer-Reviewed Original ResearchConceptsMembrane traffickingRab GTPasesCellular responsesRab GTPase functionGTPase functionMembrane compartmentsGTPasesKey regulatorSecondary consequenceHallmark of neurodegenerationTraffickingSecondary correlateDrivers of pathologyCurrent knowledgeNeurodegenerationHuntington's diseaseMembraneDifferent rolesRegulatorAlzheimer's diseaseCompartmentsDefectsHallmarkDirect consequenceFunction
2017
The where, what, and when of membrane protein degradation in neurons
Jin E, Kiral F, Hiesinger P. The where, what, and when of membrane protein degradation in neurons. Developmental Neurobiology 2017, 78: 283-297. PMID: 28884504, PMCID: PMC5816708, DOI: 10.1002/dneu.22534.Peer-Reviewed Original Research