2022
Oxalate homeostasis
Ermer T, Nazzal L, Tio M, Waikar S, Aronson P, Knauf F. Oxalate homeostasis. Nature Reviews Nephrology 2022, 19: 123-138. PMID: 36329260, PMCID: PMC10278040, DOI: 10.1038/s41581-022-00643-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsHomeostasisHumansHyperoxaluriaKidneyOxalatesRenal DialysisRenal InsufficiencyRenal Insufficiency, ChronicConceptsKidney diseaseOxalate homeostasisAnti-inflammatory medicationsChronic kidney diseaseKidney replacement therapySudden cardiac deathProgressive kidney diseaseOutlook of patientsOxalate nephropathyCardiovascular complicationsSystemic inflammationCardiac deathReplacement therapySecondary hyperoxaluriaKidney failureElevated plasmaConsequent impairmentNovel therapeuticsPatientsDiseaseEffective elimination strategiesEndogenous sourcesHomeostasisElimination strategyExcretion
2020
Pathophysiology and Treatment of Enteric Hyperoxaluria
Witting C, Langman C, Assimos D, Baum M, Kausz A, Milliner D, Tasian G, Worcester E, Allain M, West M, Knauf F, Lieske J. Pathophysiology and Treatment of Enteric Hyperoxaluria. Clinical Journal Of The American Society Of Nephrology 2020, 16: 487-495. PMID: 32900691, PMCID: PMC8011014, DOI: 10.2215/cjn.08000520.Peer-Reviewed Original ResearchConceptsEnteric hyperoxaluriaGastrointestinal disordersBariatric surgical proceduresCurrent therapeutic optionsAvailable treatment strategiesUrinary oxalate excretionKidney stone eventsLong-term efficacyKidney Health InitiativeNew therapeutic approachesComplicated obesityDietary modificationFat malabsorptionOxalate excretionTherapeutic optionsAdverse outcomesKidney failureStone eventsTreatment strategiesDietary oxalateSurgical proceduresTherapeutic approachesSevere casesHyperoxaluriaHealth initiatives
2016
Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion
Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS. Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. Journal Of The American Society Of Nephrology 2016, 28: 242-249. PMID: 27313231, PMCID: PMC5198290, DOI: 10.1681/asn.2016030279.Peer-Reviewed Original ResearchConceptsIntestinal oxalate secretionWild-type miceCystic fibrosisIntestinal tissueOxalate secretionIncidence of hyperoxaluriaCalcium oxalate stone formationNet intestinal absorptionOxalate stone formationCoexpression of CFTRIntestinal transport processesWestern blot analysisOxalate absorptionMouse modelIntestinal absorptionGlucose absorptionUssing chambersStone formationFibrosisMiceSecretionReduced expressionCystic fibrosis transmembrane conductance regulator (CFTR) geneHyperoxaluriaPatients