2023
Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exercisePercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical dataRacial and ethnic disparities in emergency department–initiated buprenorphine across five health care systems
Holland W, Li F, Nath B, Jeffery M, Stevens M, Melnick E, Dziura J, Khidir H, Skains R, D'Onofrio G, Soares W. Racial and ethnic disparities in emergency department–initiated buprenorphine across five health care systems. Academic Emergency Medicine 2023, 30: 709-720. PMID: 36660800, PMCID: PMC10467357, DOI: 10.1111/acem.14668.Peer-Reviewed Original ResearchConceptsOpioid use disorderCommunity emergency departmentsEmergency departmentDischarge diagnosisHealth care systemHispanic patientsBlack patientsHospital typeCare systemNon-Hispanic patientsOpioid overdose deathsClinical decision support systemOpioid withdrawalPrimary outcomeMedication treatmentBuprenorphine accessED treatmentTreatment accessOverdose deathsX-waiverBuprenorphinePatientsUse disordersEthnic disparitiesSecondary analysis
2022
The Impact of Extended Treatment With Artemether-lumefantrine on Antimalarial Exposure and Reinfection Risks in Ugandan Children With Uncomplicated Malaria: A Randomized Controlled Trial
Whalen ME, Kajubi R, Goodwin J, Orukan F, Colt M, Huang L, Richards K, Wang K, Li F, Mwebaza N, Aweeka FT, Parikh S. The Impact of Extended Treatment With Artemether-lumefantrine on Antimalarial Exposure and Reinfection Risks in Ugandan Children With Uncomplicated Malaria: A Randomized Controlled Trial. Clinical Infectious Diseases 2022, 76: 443-452. PMID: 36130191, PMCID: PMC9907485, DOI: 10.1093/cid/ciac783.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrineReinfection riskArtemisinin-based combination therapyDay 7 levelsOverall drug exposureHigh transmission settingsYoung childrenAntimalarial exposureUncomplicated malariaExtended regimenRecurrent parasitemiaControlled TrialsPrimary outcomeCombination therapyKaplan-MeierDrug exposureTotal episodesUgandan childrenArtemisinin resistanceLumefantrine concentrationsPharmacodynamic studiesHigh riskPharmacokinetic parametersRecurrence riskDay 7
2020
Interrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use Disorder
Holland WC, Nath B, Li F, Maciejewski K, Paek H, Dziura J, Rajeevan H, Lu CC, Katsovich L, D'Onofrio G, Melnick ER. Interrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use Disorder. Academic Emergency Medicine 2020, 27: 753-763. PMID: 32352206, PMCID: PMC7496559, DOI: 10.1111/acem.14002.Peer-Reviewed Original ResearchConceptsOpioid use disorderComputerized clinical decision support systemsRates of EDBUP initiationUse disordersClinical decision support implementationEmergency department initiationRoutine emergency careInterrupted time series studyAdult ED patientsInterrupted time seriesClinical decision support systemElectronic health recordsClinicians' unfamiliarityED initiationDecision support implementationED dischargeOpioid withdrawalSecondary outcomesOngoing trialsPrimary outcomeAcademic EDED patientsSingle EDUnique patients
2014
A randomized controlled trial of capnography during sedation in a pediatric emergency setting
Langhan ML, Shabanova V, Li FY, Bernstein SL, Shapiro ED. A randomized controlled trial of capnography during sedation in a pediatric emergency setting. The American Journal Of Emergency Medicine 2014, 33: 25-30. PMID: 25445871, PMCID: PMC4272647, DOI: 10.1016/j.ajem.2014.09.050.Peer-Reviewed Original ResearchConceptsEpisodes of hypoventilationOxygen desaturationIntervention groupStandard monitoringPediatric emergency department patientsEmergency department patientsSedation of childrenPediatric emergency departmentPediatric emergency settingRates of interventionFrequency of interventionsRespiratory depressionPrimary outcomeDepartment patientsEmergency departmentProcedural sedationEmergency settingHigher oddsHypoventilationCapnography monitorControl groupSedationStandard modalityTimely interventionCapnographyReversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels