2016
Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models
Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Molecular Psychiatry 2016, 23: 271-281. PMID: 27752082, PMCID: PMC5395367, DOI: 10.1038/mp.2016.163.Peer-Reviewed Original ResearchConceptsBrain-specific tyrosine phosphataseDephosphorylation of GluN2BExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Glutamate receptor internalizationPluripotent stem cellsKnockout mouse modelTyrosine phosphataseMouse modelKinase 1/2Receptor internalizationImportant regulatorGenetic reductionLoss of NMDARsStem cellsN-methyl DPharmacological inhibitionProtein levelsSynaptic functionSTEP61Patient cohortForebrain neuronsBehavioral deficitsExcitatory neuronsSchizophrenia model
2015
Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway
Xu J, Kurup P, Foscue E, Lombroso PJ. Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Journal Of Neurochemistry 2015, 134: 629-641. PMID: 25951993, PMCID: PMC4516628, DOI: 10.1111/jnc.13160.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseProtein kinase ARegulation of FynTyrosine phosphataseReceptor-type protein tyrosine phosphatase alphaProtein tyrosine phosphatase alphaStriatal-enriched protein tyrosine phosphataseRegulatory tyrosine residuesActivation of FynTyrosine kinase FynRegulatory tyrosineProtein tyrosinePTPαKinase FynSynaptic membranesKinase ATyrosine residuesFyn activityFynNovel substratePrimary neuronal culturesSTEP61Synergistic regulationMolecular techniquesNovel mechanism
2012
Characterization of a semi-rapid method for assessing delay discounting in rodents
Foscue E, Wood K, Schramm-Sapyta N. Characterization of a semi-rapid method for assessing delay discounting in rodents. Pharmacology Biochemistry And Behavior 2012, 101: 187-192. PMID: 22266769, PMCID: PMC3288622, DOI: 10.1016/j.pbb.2012.01.006.Peer-Reviewed Original ResearchConceptsImportant disease processesChronic treatmentRodent modelsPsychiatric disordersDisease processDaily sessionsStable response patternsDrug addictionUnderlying mechanismSession learningOperant responseFuture studiesResponse patternsStable baselineExtended trainingCompulsive gamblingSubsequent daily sessionsObesityBaselineMonthsCocaine
2011
Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine
Drescher C, Foscue E, Kuhn C, Schramm-Sapyta N. Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine. Developmental Cognitive Neuroscience 2011, 1: 600-605. PMID: 21927632, PMCID: PMC3173773, DOI: 10.1016/j.dcn.2011.05.004.Peer-Reviewed Original ResearchConceptsIndividual differencesApproach/avoidance behaviorComplex motivational statesApproach/avoidanceCocaine-induced locomotor effectsAversive effectsTaste aversion taskInterindividual differencesBrain cocaine levelsMotivational stateMotivational effectsDrugs of abuseAvoidance behaviorNeurological processesLocomotor effectsTaste aversionTaskAdulthoodDevelopmental variationAbuseCocaineAdolescenceAdolescentsAvoidanceCocaine levels
2010
Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking
Schramm‐Sapyta N, DiFeliceantonio AG, Foscue E, Glowacz S, Haseeb N, Wang N, Zhou C, Kuhn CM. Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking. Alcohol Clinical And Experimental Research 2010, 34: 2061-2069. PMID: 20860614, PMCID: PMC2988872, DOI: 10.1111/j.1530-0277.2010.01302.x.Peer-Reviewed Original ResearchConceptsAversive effectsAdolescents Versus AdultsProblem drinking behaviorDrug seeking behaviorBlood ethanol concentrationTaste aversionFuture drinkingAdolescent ratsAge differencesDrugs of abuseEthanol CTADrug takingDrinking behaviorAdolescentsPhysiologic effectsAdult ratsTeenage yearsIndividual variationRodent studiesAbuseAdultsSeeking behaviourDrug intakeEpidemiological evidenceSedative effects