2017
Single-molecule force spectroscopy of protein-membrane interactions
Ma L, Cai Y, Li Y, Jiao J, Wu Z, O'Shaughnessy B, De Camilli P, Karatekin E, Zhang Y. Single-molecule force spectroscopy of protein-membrane interactions. ELife 2017, 6: e30493. PMID: 29083305, PMCID: PMC5690283, DOI: 10.7554/elife.30493.Peer-Reviewed Original ResearchConceptsProtein-membrane interactionsC2 domainPlasma membraneMultiple C2 domainsSingle-molecule force spectroscopy approachSingle-molecule force spectroscopyOptical tweezersE-SytsUnprecedented spatiotemporal resolutionForce spectroscopyMembrane bindingMembrane fusionSingle proteinSynaptotagmin-1Biological processesEndoplasmic reticulumSpectroscopy approachLipid exchangeSynaptic vesiclesSynaptotagmin 2ProteinSilica beadsMechanical forcesHigh-resolution methodsSpatiotemporal resolution
2012
Cooperativity of SNARE Complexes in Membrane Fusion: Mechanisms of SNARE Cluster-Mediated Docking and Fusion
Warner J, Stratton B, Karatekin E, O'Shaughnessy B. Cooperativity of SNARE Complexes in Membrane Fusion: Mechanisms of SNARE Cluster-Mediated Docking and Fusion. Biophysical Journal 2012, 102: 498a-499a. DOI: 10.1016/j.bpj.2011.11.2729.Peer-Reviewed Original Research