2025
A randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes
Klimczak A, Osman E, Esbert M, Yildirim R, Whitehead C, Herlihy N, Hanson B, Roberts L, Seli E, Scott R. A randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes. Human Reproduction 2025, deaf003. PMID: 39836897, DOI: 10.1093/humrep/deaf003.Peer-Reviewed Original ResearchFrozen embryo transferRandomized controlled trialsPregnancy outcomesIVF stimulationPre-clinical trialsEmbryo transferPregnancy rateFutility analysisPost-warming survival rateDATE OF FIRST PATIENT’S ENROLMENT:University-affiliated infertility centerClinical pregnancy rateEmbryo transfer outcomesSustained implantation ratesPreimplantation genetic testingFIRST PATIENT’S ENROLMENTBlastocyst biopsyEmbryological outcomesBlastocyst survivalEmbryo vitrificationHuman oocytesMiscarriage rateImplantation rateNo significant differenceBaseline characteristics
2024
Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial
Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.Peer-Reviewed Original ResearchPoor ovarian responseControlled ovarian stimulationHistory of poor ovarian responsePremature ovarian insufficiencyPlatelet-rich plasmaPlatelet-rich plasma injectionsMature oocyte yieldRandomized controlled trialsPRP injectionEuploid blastocystsOvarian responseOocyte yieldOocyte retrievalIVF outcomesIntraovarian platelet-rich plasmaUniversity-affiliated reproductive centerIVF historyMature oocytesSustained implantationDATE OF FIRST PATIENT’S ENROLMENT:Euploid embryo transferInclusion criteriaPlatelet-rich plasma preparationsPreimplantation genetic testingOvarian reserve tests