2022
Guidelines for Reporting Outcomes in Trial Protocols
Butcher N, Monsour A, Mew E, Chan A, Moher D, Mayo-Wilson E, Terwee C, Chee-A-Tow A, Baba A, Gavin F, Grimshaw J, Kelly L, Saeed L, Thabane L, Askie L, Smith M, Farid-Kapadia M, Williamson P, Szatmari P, Tugwell P, Golub R, Monga S, Vohra S, Marlin S, Ungar W, Offringa M. Guidelines for Reporting Outcomes in Trial Protocols. JAMA 2022, 328: 2345-2356. PMID: 36512367, DOI: 10.1001/jama.2022.21243.Peer-Reviewed Original ResearchGuidelines for Reporting Outcomes in Trial Reports
Butcher N, Monsour A, Mew E, Chan A, Moher D, Mayo-Wilson E, Terwee C, Chee-A-Tow A, Baba A, Gavin F, Grimshaw J, Kelly L, Saeed L, Thabane L, Askie L, Smith M, Farid-Kapadia M, Williamson P, Szatmari P, Tugwell P, Golub R, Monga S, Vohra S, Marlin S, Ungar W, Offringa M. Guidelines for Reporting Outcomes in Trial Reports. JAMA 2022, 328: 2252-2264. PMID: 36511921, DOI: 10.1001/jama.2022.21022.Peer-Reviewed Original ResearchConceptsCONSORT 2010 statementClinical trialsConsensus meetingTrial reportsTrial outcomesReporting outcomesReporting Trials (CONSORT) 2010 statementTrial resultsElectronic database searchReporting of outcomesPerson consensus meetingCochrane Methodology RegisterGrey literature searchReference list searchesPrespecified analysisSecondary outcomesConsensus-based standardsDelphi survey processConsolidated StandardsDelphi votingTreatment groupsOutcome selectionFurther evaluationEvidence-informed decisionLiterature searchPsychosocial family-level mediators in the intergenerational transmission of trauma: Protocol for a systematic review and meta-analysis
Mew E, Nyhan K, Bonumwezi J, Blas V, Gorman H, Hennein R, Quach K, Shabanova V, Hawley N, Lowe S. Psychosocial family-level mediators in the intergenerational transmission of trauma: Protocol for a systematic review and meta-analysis. PLOS ONE 2022, 17: e0276753. PMID: 36378630, PMCID: PMC9665367, DOI: 10.1371/journal.pone.0276753.Peer-Reviewed Original ResearchConceptsChild mental health outcomesSystematic review registrationRelevant study characteristicsMental health outcomesParental trauma exposureReview registrationBias assessmentRegistration IDConference abstractsPeer-reviewed publicationsPsychosocial factorsFamily-level factorsHealth outcomesSystematic reviewNarrative synthesisPsychosocial mediatorsPublication biasTrauma exposureStudy characteristicsEpidemiological researchProQuest DissertationsTraumaTrauma typesPsychological impactMediators
2021
Emergency care with lay responders in underserved populations: a systematic review
Orkin A, Venugopal J, Curran J, Fortune M, McArthur A, Mew E, Ritchie S, Drennan I, Exley A, Jamieson R, Johnson D, MacPherson A, Martiniuk A, McDonald N, Osei-Ampofo M, Wegier P, Van de Velde S, VanderBurgh D. Emergency care with lay responders in underserved populations: a systematic review. Bulletin Of The World Health Organization 2021, 99: 514-528h. PMID: 34248224, PMCID: PMC8243031, DOI: 10.2471/blt.20.270249.Peer-Reviewed Original ResearchConceptsLow-resource settingsEmergency careOpioid poisoningUnderserved populationsLow-resource populationsEmergency care trainingCommunity health effectsPediatric malariaMiddle-income countriesCardiac arrestPatient morbidityStudy eligibilityEligible studiesPatient outcomesHigh-income countriesInclusion criteriaAdditional grey literatureHealth of individualsRisk populationsCare professionalsModerate qualitySystematic reviewCommunicable diseasesCare trainingMost studies
2020
Development of an international standard set of patient-centred outcome measures for overall paediatric health: a consensus process
Algurén B, Ramirez J, Salt M, Sillett N, Myers S, Alvarez-Cote A, Butcher N, Caneo L, Cespedes J, Chaplin J, Ng K, García-García J, Hazelzet J, Klassen A, Turquetto A, Mew E, Morris M, Offringa M, O'Meara M, Papp J, Rodrigo C, Switaj T, Mayer C, Jenkins K. Development of an international standard set of patient-centred outcome measures for overall paediatric health: a consensus process. Archives Of Disease In Childhood 2020, 106: 868-876. PMID: 33310707, PMCID: PMC8380885, DOI: 10.1136/archdischild-2020-320345.Peer-Reviewed Original ResearchConceptsOutcome measuresPatient-centered outcome measuresDelphi processHealth Professional SurveyPatient-reported outcomesCase-mix variablesClinician-reported measuresField of pediatricsHealth Outcomes MeasurementAdolescent physical healthWorking GroupInternational Working GroupClinical trialsPediatric healthcare deliveryProxy-reported outcomesHealth SurveyPediatric healthInternational standard setOutcome measurementsPatient advisorsBiopsychosocial aspectsPatient validationPhysical healthHealth conditionsFamily medicineResponse to “Trials for depressive disorder in adolescents: the emperor's new clothes,” a letter to the editor by Alain Braillon, MD, PhD
Butcher N, Mew E, Monsour A, Szatmari P, Monga S, Offringa M, co-authors A. Response to “Trials for depressive disorder in adolescents: the emperor's new clothes,” a letter to the editor by Alain Braillon, MD, PhD. Journal Of Clinical Epidemiology 2020, 128: 159-161. PMID: 32860976, PMCID: PMC7449977, DOI: 10.1016/j.jclinepi.2020.08.010.Peer-Reviewed Original ResearchOutcome reporting recommendations for clinical trial protocols and reports: a scoping review
Butcher N, Mew E, Monsour A, Chan A, Moher D, Offringa M. Outcome reporting recommendations for clinical trial protocols and reports: a scoping review. Trials 2020, 21: 620. PMID: 32641085, PMCID: PMC7341657, DOI: 10.1186/s13063-020-04440-w.Peer-Reviewed Original ResearchConceptsClinical trial protocolTrial protocolTrial outcomesStandard Protocol ItemsReporting of outcomesElectronic bibliographic database searchConsensus-based guidanceFull-text screeningGrey literature searchInterventional trialsResultsIn totalClinical trialsBibliographic database searchConsolidated StandardsProtocol ItemsCandidate itemsOutcome selectionAbstract screeningLiterature searchOutcomesResearch wasteSystematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials
Mew E, Monsour A, Saeed L, Santos L, Patel S, Courtney D, Watson P, Szatmari P, Offringa M, Monga S, Butcher N. Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials. Journal Of Clinical Epidemiology 2020, 126: 71-79. PMID: 32561367, DOI: 10.1016/j.jclinepi.2020.06.013.Peer-Reviewed Original ResearchConceptsOutcome measurement instrumentsOutcome heterogeneityMajor depressive disorder trialsMajor depressive disorderDepressive symptom severityOutcome termsSingle trialDepression clinical trialPrimary outcomeClinical trialsDepressive disorderDepression trialsSymptom severityLife impactStudy designIdentified outcomesTrial resultsTrialsOutcomesIdentifies heterogeneityDescriptive analysisMeasurement instrumentsTherapySeverityPrimary outcome reporting in adolescent depression clinical trials needs standardization
Monsour A, Mew E, Patel S, Chee-a-tow A, Saeed L, Santos L, Courtney D, Watson P, Monga S, Szatmari P, Offringa M, Butcher N. Primary outcome reporting in adolescent depression clinical trials needs standardization. BMC Medical Research Methodology 2020, 20: 129. PMID: 32450810, PMCID: PMC7247139, DOI: 10.1186/s12874-020-01019-6.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPrimary outcomeSingle primary outcomeClinical trialsOutcome assessmentDiagnosis of MDDChecklist itemsOutcome assessorsDepression clinical trialClinical guidelinesAdolescent MDDOutcome analysisRCT publicationsMost trialsTrial publicationsOutcome reportingReporting ItemsTreatment interventionsTrial outcomesOutcome informationTrialsHealth careOutcomesSignificant differencesMinimal criteriaNeurodevelopmental outcome descriptions in cohorts of extremely preterm children
Ding S, Mew E, Chee-A-Tow A, Offringa M, Butcher N, Moore G. Neurodevelopmental outcome descriptions in cohorts of extremely preterm children. Archives Of Disease In Childhood Fetal & Neonatal 2020, 105: fetalneonatal-2019-318144. PMID: 31932362, DOI: 10.1136/archdischild-2019-318144.Peer-Reviewed Original ResearchConceptsCohort studyCerebral palsyCognitive functionNeurodevelopmental outcomesOutcome selectionProspective cohort studyLong-term followOutcome descriptionsCompleteness of outcomeCompleteness of reportingOutcome assessorsPreterm infantsPreterm birthOutcome definitionsPreterm childrenOutcome reportingPalsyOutcomesInfantsChildrenReportingPretermStudy resultsCohortFollow
2019
Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT)
Butcher NJ, Monsour A, Mew EJ, Szatmari P, Pierro A, Kelly LE, Farid-Kapadia M, Chee-a-tow A, Saeed L, Monga S, Ungar W, Terwee CB, Vohra S, Fergusson D, Askie LM, Williamson PR, Chan AW, Moher D, Offringa M. Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT). Trials 2019, 20: 161. PMID: 30841935, PMCID: PMC6404348, DOI: 10.1186/s13063-019-3248-0.Peer-Reviewed Original ResearchConceptsClinical trialsTrial protocolTrial reportsExpert consensus meetingClinical trial reportsCONSORT reporting guidelinesIntegrated knowledge translation approachSystematic review authorsKnowledge translation approachReview authorsConsensus-based standardsPatient outcomesConsensus meetingDiverse disease areasInternational Delphi studyTrial designGuideline developersGuideline developmentCONSORT extensionDelphi studyTrial outcomesEQUATOR NetworkCandidate outcomesTrialsPoor quality outcomesGuidance for reporting outcomes in clinical trials: scoping review protocol
Butcher NJ, Mew EJ, Saeed L, Monsour A, Chee-A-Tow A, Chan AW, Moher D, Offringa M. Guidance for reporting outcomes in clinical trials: scoping review protocol. BMJ Open 2019, 9: e023001. PMID: 30782872, PMCID: PMC6377514, DOI: 10.1136/bmjopen-2018-023001.Peer-Reviewed Original ResearchOutcomes reported in randomised clinical trials of major depressive disorder treatments in adolescents: a systematic scoping review protocol
Monsour A, Mew EJ, Szatmari P, Patel S, Saeed L, Offringa M, Butcher NJ. Outcomes reported in randomised clinical trials of major depressive disorder treatments in adolescents: a systematic scoping review protocol. BMJ Open 2019, 9: bmjopen-2018-024191. PMID: 30782729, PMCID: PMC6340428, DOI: 10.1136/bmjopen-2018-024191.Peer-Reviewed Original ResearchConceptsAdolescent major depressive disorderCore outcome setsMajor depressive disorderClinical trialsMajor depressive disorder treatmentCommon mental health conditionsDepressive disorder treatmentBest treatment practicesMental health conditionsElectronic bibliographic database searchJoanna Briggs InstituteReview methods manualFull-text screeningEfficacy of interventionsSystematic scoping review protocolScoping review protocolSystematic scoping reviewDepressive disorderEligible studiesBibliographic database searchOutcome setsTreatment interventionsDisorder treatmentOutcome selectionRCTs
2018
Defining and measuring health equity effects in research on task shifting interventions in high-income countries: a systematic review protocol
Orkin AM, McArthur A, McDonald A, Mew EJ, Martiniuk A, Buchman DZ, Kouyoumdjian F, Rachlis B, Strike C, Upshur R. Defining and measuring health equity effects in research on task shifting interventions in high-income countries: a systematic review protocol. BMJ Open 2018, 8: e021172. PMID: 30068611, PMCID: PMC6074666, DOI: 10.1136/bmjopen-2017-021172.Peer-Reviewed Original ResearchConceptsPROGRESS-Plus frameworkHealth equityHigh-income countriesBaseline statusHealth inequitiesOpen-access peer-reviewed publicationHigh-income settingsHealth equity effectsSystematic review protocolQuality of reportingDisease burdenEligible studiesEffective treatmentPeer-reviewed publicationsAcademic conference presentationsHealth disadvantageSystematic reviewNarrative synthesisAbstract screeningReview protocolIntervention impactManual searchingInterventionHuman subjectsDuplicate titles
2017
The global burden of fatal self-poisoning with pesticides 2006-15: Systematic review
Mew EJ, Padmanathan P, Konradsen F, Eddleston M, Chang SS, Phillips MR, Gunnell D. The global burden of fatal self-poisoning with pesticides 2006-15: Systematic review. Journal Of Affective Disorders 2017, 219: 93-104. PMID: 28535450, DOI: 10.1016/j.jad.2017.05.002.Peer-Reviewed Original ResearchAn environmental scan of emergency response systems and services in remote First Nations communities in Northern Ontario
Mew EJ, Ritchie SD, VanderBurgh D, Beardy JL, Gordon J, Fortune M, Mamakwa S, Orkin AM. An environmental scan of emergency response systems and services in remote First Nations communities in Northern Ontario. International Journal Of Circumpolar Health 2017, 76: 1320208. PMID: 28494638, PMCID: PMC5497541, DOI: 10.1080/22423982.2017.1320208.Peer-Reviewed Original ResearchMeSH KeywordsAmbulancesArctic RegionsBurnout, ProfessionalCommunity-Based Participatory ResearchEmergency Medical DispatchEmergency Medical ServicesEmergency Medical TechniciansHealth Services AccessibilityHealth Services, IndigenousHealth WorkforceHealthcare DisparitiesHumansIndians, North AmericanOntarioPersonnel SelectionQualitative ResearchRural Health ServicesVolunteersConceptsFirst Nations communitiesNations communitiesCommunity-based participatory researchRemote Indigenous communitiesVolunteer emergency servicesEmergency care systemKey informant interviewsRemote First Nations communitiesEmergency response systemPolitical groupingsIndigenous communitiesParticipatory researchInformant interviewsEnvironmental scan approachInterview dataCultural needsCommunity health leadersCare systemNorthern OntarioResponse capacityRoad accessCommunityQualitative analysisHealth leadersFirst aid training
2016
Health effects of training laypeople to deliver emergency care in underserviced populations: a systematic review protocol
Orkin AM, Curran JD, Fortune MK, McArthur A, Mew EJ, Ritchie SD, Van de Velde S, VanderBurgh D. Health effects of training laypeople to deliver emergency care in underserviced populations: a systematic review protocol. BMJ Open 2016, 6: e010609. PMID: 27194315, PMCID: PMC4874171, DOI: 10.1136/bmjopen-2015-010609.Peer-Reviewed Original ResearchConceptsLow-resource settingsEmergency care trainingUnderserviced populationsCare trainingDisease Control Priorities ProjectHealth effectsEmergency care capacityEmergency care interventionsEmergency health conditionsCommunity health effectsSystematic review protocolFull-text reviewFormal ethical approvalKnowledge translation strategiesElectronic bibliographic databasesCommunity health benefitsGrey literature sourcesCare interventionsCare capacityEmergency careEthical approvalPeer-reviewed publicationsPerformance biasAttrition biasSystematic review