2024
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Chowdhury S, Sirotich E, Guyatt G, Gill D, Modi D, Venier L, Mahamad S, Chowdhury M, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, ‐DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Agarwal A, Nazaryan H, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Shafiee A, Rathod P, Kwon H, Dookie J, Zeraatkar D, Thabane L, Couban R, Arnold D. Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review. European Journal Of Haematology 2024 PMID: 39552264, DOI: 10.1111/ejh.14351.Peer-Reviewed Original ResearchImmune thrombocytopeniaCritical bleedingTPO-RAsPlatelet transfusionsCritically bleeding patientsPlatelet count responseSystematic reviewReview of treatmentBleeding patientsIVIGEvidence-based protocolsBleedingBleeding emergenciesCorticosteroidsSystematic review of treatmentsPatientsSplenectomyPatient outcomesIndividualized treatmentThrombocytopeniaPlateletTransfusionEffects of individual treatmentsTreatmentStudy designTreatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis
Sirotich E, Nazaryan H, Chowdhury S, Guyatt G, Agarwal A, Leong R, Wen A, Xu E, Liu B, Pallapothu S, Rathod P, Kwon H, Dookie J, Shafiee A, Charness J, DiRaimo J, Paynter D, Pruitt B, Strachan G, Couban R, Ye Z, Arnold D. Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis. Systematic Reviews 2024, 13: 21. PMID: 38184622, PMCID: PMC10770981, DOI: 10.1186/s13643-023-02436-6.Peer-Reviewed Original ResearchConceptsCritical bleedingSystematic reviewEvidence-based treatment protocolsBleeding-related mortalityCochrane Central RegisterEvidence-based recommendationsFull-text screeningBleeding eventsImmune thrombocytopeniaRecommendations AssessmentCentral RegisterControlled TrialsPrimary outcomeSevere thrombocytopeniaPlatelet countEligible studiesPatient outcomesEmergency settingOvid MEDLINEObservational studyTreatment protocolHigh riskMedical emergencyElectronic databasesMethodsLiterature search
2023
Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis
Nazaryan H, Watson M, Ellingham D, Thakar S, Wang A, Pai M, Liu Y, Rochwerg B, Gabarin N, Arnold D, Sirotich E, Zeller M. Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis. Systematic Reviews 2023, 12: 121. PMID: 37443063, PMCID: PMC10347734, DOI: 10.1186/s13643-023-02222-4.Peer-Reviewed Original ResearchConceptsIron deficiency anemiaQuality of lifeHeavy menstrual bleedingStandard of carePatient outcomesIron interventionsSystematic reviewUterine bleedingCombination therapyIron supplementationIron indicesRed blood cell transfusionIron deficiencyRed blood cell utilizationAbnormal uterine bleedingIntraoperative blood lossBlood cell transfusionEvidence-based clinical practiceMeta-analyzed outcomesSystematic literature searchCost of treatmentWeb of ScienceCell transfusionHospital stayAdverse events
2019
Impact of Iron Supplementation on Patient Outcomes in Women Undergoing Gynecological Procedures: Systematic Review and Meta-Analysis of Randomized Trials
Sirotich E, Jamula E, Wang A, Arnold D, Zeller M. Impact of Iron Supplementation on Patient Outcomes in Women Undergoing Gynecological Procedures: Systematic Review and Meta-Analysis of Randomized Trials. Blood 2019, 134: 59. DOI: 10.1182/blood-2019-122269.Peer-Reviewed Original ResearchPerioperative RBC transfusionPreoperative Hb levelErythropoietin-stimulating agentsRBC transfusion ratesAdverse eventsIron supplementationGynecological proceduresRBC transfusionPatient outcomesHb levelsSystematic reviewPostoperative HbTransfusion rateHemoglobin levelsIron supplementsPerioperative red blood cell transfusionIncidence of AEsOccurrence of AEsRed blood cell transfusionNumber of AEsPatient blood management strategiesPostoperative Hb levelsPreoperative iron supplementationBlood cell transfusionRisk of anemia