2024
Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis
Sirotich E, Nazaryan H, Chowdhury S, Guyatt G, Agarwal A, Leong R, Wen A, Xu E, Liu B, Pallapothu S, Rathod P, Kwon H, Dookie J, Shafiee A, Charness J, DiRaimo J, Paynter D, Pruitt B, Strachan G, Couban R, Ye Z, Arnold D. Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis. Systematic Reviews 2024, 13: 21. PMID: 38184622, PMCID: PMC10770981, DOI: 10.1186/s13643-023-02436-6.Peer-Reviewed Original ResearchConceptsCritical bleedingSystematic reviewEvidence-based treatment protocolsBleeding-related mortalityCochrane Central RegisterEvidence-based recommendationsFull-text screeningBleeding eventsImmune thrombocytopeniaRecommendations AssessmentCentral RegisterControlled TrialsPrimary outcomeSevere thrombocytopeniaPlatelet countEligible studiesPatient outcomesEmergency settingOvid MEDLINEObservational studyTreatment protocolHigh riskMedical emergencyElectronic databasesMethodsLiterature search
2023
Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review
Sirotich E, Chowdhury S, Guyatt G, Gill D, Modi D, Venier L, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Nazaryan H, Agarwal A, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Rathod P, Kwon H, Dookie J, Shafiee A, Couban R, Arnold D. Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review. Blood 2023, 142: 7239. DOI: 10.1182/blood-2023-179448.Peer-Reviewed Original ResearchPlatelet count responseTPO-RAsImmune thrombocytopeniaPlatelet transfusionsCritical bleedingBleed resolutionTreated with platelet transfusionsPatients treated with splenectomyControlled trialsCritical bleeding eventsManagement of critical bleedingTPO receptor agonistsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsSystematic reviewTreatment of critical bleedingCochrane Central RegisterReview of treatmentEvidence-based treatment protocolsClinical practice guidelinesRandomized controlled trialsCount responseIntraperitoneal bleedingOcular bleeding