2024
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford M, Estcourt L, Sirotich E, Pitre T, Britto J, Watson M, Brunskill S, Fergusson D, Dorée C, Arnold D. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. 2024, 2024: cd011305. PMID: 38780066, PMCID: PMC11112982, DOI: 10.1002/14651858.cd011305.pub3.Peer-Reviewed Original ResearchConceptsRed blood cell transfusion strategyHaematopoietic stem cell transplantationLiberal transfusion strategyClinically significant bleedingRestrictive transfusion strategyNon-randomised studiesTransfusion strategyIntensive chemotherapyRandomised controlled trialsRed blood cellsSignificant bleedingAll-cause mortalityLength of hospital admissionAcute leukemiaHaematological malignanciesRisk of clinically significant bleedingHaematopoietic stem cell supportProspective non-randomised studyRisk ratioControlled trialsQuality of lifeStem cell supportStem cell transplantationMalignant haematological disordersCochrane Central Register of Controlled Trials
2023
Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review
Sirotich E, Chowdhury S, Guyatt G, Gill D, Modi D, Venier L, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Nazaryan H, Agarwal A, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Rathod P, Kwon H, Dookie J, Shafiee A, Couban R, Arnold D. Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review. Blood 2023, 142: 7239. DOI: 10.1182/blood-2023-179448.Peer-Reviewed Original ResearchPlatelet count responseTPO-RAsImmune thrombocytopeniaPlatelet transfusionsCritical bleedingBleed resolutionTreated with platelet transfusionsPatients treated with splenectomyControlled trialsCritical bleeding eventsManagement of critical bleedingTPO receptor agonistsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsSystematic reviewTreatment of critical bleedingCochrane Central RegisterReview of treatmentEvidence-based treatment protocolsClinical practice guidelinesRandomized controlled trialsCount responseIntraperitoneal bleedingOcular bleeding