2011
Chiral Sum Frequency Generation Spectroscopy for Characterizing Protein Secondary Structures at Interfaces
Fu L, Liu J, Yan EC. Chiral Sum Frequency Generation Spectroscopy for Characterizing Protein Secondary Structures at Interfaces. Journal Of The American Chemical Society 2011, 133: 8094-8097. PMID: 21534603, DOI: 10.1021/ja201575e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleHumansIslet Amyloid PolypeptideMembrane ProteinsProtein Structure, SecondaryRhodopsinSpectrum AnalysisSurface PropertiesVibrationConceptsChiral sum frequency generation (SFG) spectroscopySum frequency generation spectroscopyFrequency generation spectroscopyProtein secondary structureVibrational signaturesGeneration spectroscopyChiral SFG spectroscopyChiral SFG spectraRandom coilSecondary structureΑ-helixΒ-sheetLipid-water interfaceSFG spectroscopyHuman islet amyloidPeptide backboneSFG spectraH stretchAmide IReal-time characterizationSpectroscopyProtein conformationIslet amyloidStructureSitu
2010
In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation
Fu L, Ma G, Yan EC. In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation. Journal Of The American Chemical Society 2010, 132: 5405-5412. PMID: 20337445, DOI: 10.1021/ja909546b.Peer-Reviewed Original ResearchMeSH KeywordsAmyloidHumansIslet Amyloid PolypeptideKineticsPhosphatidylglycerolsProtein ConformationProtein FoldingSpectrum AnalysisConceptsChiral optical responseSum-frequency generationCharacteristic optical propertiesSum frequency generation spectroscopyVibrational sum frequency generationAir/water interfaceFrequency generationOptical propertiesFrequency generation spectroscopyPolarization settingsGeneration spectroscopyWater interfaceInterface ProbedChiral structureStretch frequencyParallel beta-sheet structure