2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAnxiety DisordersBrain MappingChildHumansMagnetic Resonance ImagingPrefrontal CortexConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy
Kitt ER, Lewis KM, Galbraith J, Abend R, Smith AR, Lebowitz ER, Pine DS, Gee DG. Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy. Behaviour Research And Therapy 2022, 154: 104107. PMID: 35613517, PMCID: PMC9271364, DOI: 10.1016/j.brat.2022.104107.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildFamilyFamily RelationsHumansRisk AssessmentSelf EfficacyConceptsFamily accommodationPediatric anxietyAnxiety disordersNon-anxious controlsClinician ratingsPediatric anxiety disordersReal-world behaviorImportant preliminary insightsBody of researchLaboratory tasksMediation modelGreater avoidanceAge 8AnxietyDistinct measuresUntested relationsFuture researchYouthRobust associationAvoidanceBehavioral factorsRatingsPreliminary insightsEarly identificationDisorders
2021
Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAnxiety DisordersEndocannabinoidsFemaleHumansMagnetic Resonance ImagingMalePolymorphism, Single NucleotideConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivityLeveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiology
2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal modelsComparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortexDevelopmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety
Gee DG, Kribakaran S. Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety. American Journal Of Psychiatry 2020, 177: 378-380. PMID: 32354263, DOI: 10.1176/appi.ajp.2020.20020225.Peer-Reviewed Original Research
2019
Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions
Kribakaran S, Danese A, Bromis K, Kempton MJ, Gee DG. Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 23-34. PMID: 31690501, PMCID: PMC6954289, DOI: 10.1016/j.bpsc.2019.08.006.Peer-Reviewed Original ResearchConceptsPediatric PTSDPediatric posttraumatic stress disorderPTSD groupTrauma exposurePosttraumatic stress disorderHippocampal volumeVolumetric brain differencesStructural magnetic resonance imaging (MRI) studiesStructural brain volumesMagnetic resonance imaging studyResonance imaging studySmaller total gray matterPediatric anxietyPosttraumatic stressAnxiety groupStress disorderNeurobiological differencesBrain differencesSmaller hippocampal volumesPediatric psychiatric conditionsTemporal lobeEffect of agePediatric depressionPsychiatric conditionsComparison groupNovel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood
Cohodes EM, Abusch A, Odriozola P, Gee DG. Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood. Clinical Child Psychology And Psychiatry 2019, 25: 189-199. PMID: 30696260, PMCID: PMC6667310, DOI: 10.1177/1359104518822685.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAdolescentAnxietyAnxiety DisordersChildCross-Sectional StudiesFemaleHumansMaleSleepConceptsSleep quantitySleep-related interventionsSleep functionPredictors of anxietyPediatric clinical samplesAge-related changesHigh anxietyAnxietyPediatric samplesPrevious researchSleep dysfunctionClinical samplesChildhoodFunction changesAdolescenceAdolescentsActigraphyPresent studyYouthQuantitative measuresCorrelatesAssociationSleepChildrenIntervention
2018
Implications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildHumansNational Institute of Mental Health (U.S.)United StatesConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach