2021
Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiology
2019
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
Meyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26970-26979. PMID: 31822612, PMCID: PMC6936350, DOI: 10.1073/pnas.1910481116.Peer-Reviewed Original ResearchCompound cueAnxiety disordersPrelimbic cortexSafety signal learningCurrent evidence-based treatmentsVentromedial prefrontal cortexCognitive behavioral therapyAlternative neural mechanismVentral hippocampal neuronsPresence of threatNeural activity patternsEvidence-based treatmentsAnxious individualsThreat cuesEvidence-based interventionsSafety learningFear extinctionVentral hippocampusThreat responsesSignal learningNeural mechanismsBehavioral therapyInhibition paradigmPrefrontal cortexHippocampal responses