2022
Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2017
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.Peer-Reviewed Original ResearchConceptsAnxiety-related behaviorDevelopmental trajectoriesAdolescent brain developmentRegulation of fearConsequences of stressGenetic variationBrain developmentBehavioral processingECB systemPrefrontal cortexEmotional behaviorHuman genetic variationCorticolimbic structuresStress responsivityBrain regionsAdolescenceRegulation of stressNeural circuitsEndocannabinoid systemAnxietyEnvironmental perturbationsRole of eCBFunctional implicationsCentral roleLife span
2013
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes