2009
Baseline brain energy supports the state of consciousness
Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthesiaAnimalsBehavior, AnimalBrainBrain MappingConsciousnessEnergy MetabolismHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyNeuronsPositron-Emission TomographyRatsConceptsLoss of consciousnessBrain energyConscious stateHigh-frequency neuronal activityCerebral energy consumptionBrain energy consumptionCerebral energyEnsembles of neuronsRat brainSomatosensory responsesNeuronal activityGamma-band rangeNeuronal propertiesFiring rateSensory stimulationNeuronal signalingPET measurementsAnesthesiaFMRI patternsFMRI activity patternsOxygen consumptionState of consciousnessStimulationBehavioral abilitiesMagnetic resonance spectroscopyChapter 21 Assessment of In Vivo Mitochondrial Metabolism by Magnetic Resonance Spectroscopy
Befroy DE, Petersen K, Rothman DL, Shulman GI. Chapter 21 Assessment of In Vivo Mitochondrial Metabolism by Magnetic Resonance Spectroscopy. Methods In Enzymology 2009, 457: 373-393. PMID: 19426879, PMCID: PMC3077057, DOI: 10.1016/s0076-6879(09)05021-6.Peer-Reviewed Original Research
2001
Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After Stroke
Graham G, Hwang J, Rothman D, Prichard J. Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After Stroke. Stroke 2001, 32: 2797-2802. PMID: 11739976, DOI: 10.1161/hs1201.099414.Peer-Reviewed Original ResearchGlutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Patel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.Peer-Reviewed Original ResearchFlux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy
Chase J, Rothman D, Shulman R. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy. AJP Endocrinology And Metabolism 2001, 280: e598-e607. PMID: 11254467, DOI: 10.1152/ajpendo.2001.280.4.e598.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon IsotopesGlucose Clamp TechniqueGlucose-6-PhosphateGlycogenGlycogen SynthaseMagnetic Resonance SpectroscopyMaleModels, BiologicalMuscle, SkeletalPhosphorusRatsRats, Sprague-DawleyConceptsGlycogen synthesisGlycogen synthesis pathwayInsulin-stimulated muscle glycogen synthesisMetabolic control analysisMuscle glycogen synthesisGlycogen synthaseSynthesis pathwayGlycogen synthesis rateFlux controlGSaseHyperglycemic glucose concentrationsSynthesis rateControl coefficientsHexokinaseRat gastrocnemius muscleRelative contributionNMR spectroscopyGlycolysisSynthasePathwayIn vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
2000
Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis
Pan J, Rothman D, Behar K, Stein D, Hetherington H. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1502-1507. PMID: 11043913, DOI: 10.1097/00004647-200010000-00012.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAdultBrainFastingHumansKetosisLactic AcidMagnetic Resonance SpectroscopyReference ValuesTime FactorsConceptsBHB levelsPlasma BHB levelsField magnetic resonance spectroscopyHigh-field magnetic resonance spectroscopyBrain lactateKetogenic dietCalcarine fissureNonfasted stateOccipital lobeHealthy adultsLactate increaseThird dayΒ-hydroxybutyrateKetosisBHB concentrationsBrainBHBGlucose phosphorylationLactate oxidationMagnetic resonance spectroscopy
1999
Linear projection method for automatic slice shimming
Shen J, Rothman D, Hetherington H, Pan J. Linear projection method for automatic slice shimming. Magnetic Resonance In Medicine 1999, 42: 1082-1088. PMID: 10571929, DOI: 10.1002/(sici)1522-2594(199912)42:6<1082::aid-mrm12>3.0.co;2-g.Peer-Reviewed Original ResearchBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPhantoms, ImagingIn vivo chemical shift imaging of γ‐aminobutyric acid in the human brain
Shen J, Shungu D, Rothman D. In vivo chemical shift imaging of γ‐aminobutyric acid in the human brain. Magnetic Resonance In Medicine 1999, 41: 35-42. PMID: 10025609, DOI: 10.1002/(sici)1522-2594(199901)41:1<35::aid-mrm7>3.0.co;2-c.Peer-Reviewed Original ResearchNew NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures.
Petroff O, Behar K, Rothman D. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Advances In Neurology 1999, 79: 939-45. PMID: 10514877.Peer-Reviewed Original Research
1998
In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse train
Shen J, Novotny E, Rothman D. In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse train. Magnetic Resonance In Medicine 1998, 40: 783-788. PMID: 9797163, DOI: 10.1002/mrm.1910400520.Peer-Reviewed Original ResearchFunctional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarbon IsotopesEnergy MetabolismGlucoseGlutamic AcidGlutamineGlycolysisHumansMagnetic Resonance SpectroscopyModels, BiologicalNeuronsOxidation-ReductionConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo results15N-NMR Spectroscopy Studies of Ammonia Transport and Glutamine Synthesis in the Hyperammonemic Rat Brain
Shen J, Sibson N, Cline G, Behar K, Rothman D, Shulman R. 15N-NMR Spectroscopy Studies of Ammonia Transport and Glutamine Synthesis in the Hyperammonemic Rat Brain. Developmental Neuroscience 1998, 20: 434-443. PMID: 9778582, DOI: 10.1159/000017341.Peer-Reviewed Original ResearchStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
Homocarnosine and the measurement of neuronal pH in patients with epilepsy
Rothman D, Behar K, Prichard J, Petroff O. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magnetic Resonance In Medicine 1997, 38: 924-929. PMID: 9402193, DOI: 10.1002/mrm.1910380611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain ChemistryCarnosineEpilepsyFemaleGamma-Aminobutyric AcidHumansHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMaleMiddle AgedNeuronsVigabatrinImprovements on an in Vivo automatic shimming method (FASTERMAP)
Shen J, Rycyna R, Rothman D. Improvements on an in Vivo automatic shimming method (FASTERMAP). Magnetic Resonance In Medicine 1997, 38: 834-839. PMID: 9358459, DOI: 10.1002/mrm.1910380521.Peer-Reviewed Original ResearchFast Automatic Adjustment of On-Axis Shims for High-Resolution NMR
Shen J, Rothman D. Fast Automatic Adjustment of On-Axis Shims for High-Resolution NMR. Journal Of Magnetic Resonance 1997, 127: 229-232. PMID: 9281488, DOI: 10.1006/jmre.1997.1205.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsFourier AnalysisMagnetic Resonance SpectroscopySignal Processing, Computer-AssistedIn vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling
Sibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.Peer-Reviewed Original ResearchAdiabatic Slice-Selective Excitation for Surface Coils
Shen J, Rothman D. Adiabatic Slice-Selective Excitation for Surface Coils. Journal Of Magnetic Resonance 1997, 124: 72-79. PMID: 9169211, DOI: 10.1006/jmre.1996.7483.Peer-Reviewed Original Research
1996
Human brain GABA levels rise rapidly after initiation of vigabatrin therapy
Petroff O, Rothman D, Behar K, Collins T, Mattson R. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 1996, 47: 1567-1571.. PMID: 8960747, DOI: 10.1212/wnl.47.6.1567.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrainEpilepsyGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyVigabatrinConceptsBrain GABA levelsBrain GABASingle oral doseOral doseGABA levelsSide effectsHuman brain GABA levelsEffective antiepileptic medicationsHours of administrationAntiepileptic medicationsVigabatrin therapyDay dosingIntractable epilepsySerial measurementsOccipital cortexVigabatrinDay 8Day 5GABAGABA transaminasePatientsDoseNext dayHuman brainMagnetic resonance spectroscopy