Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes.
Petroff O, Graham G, Blamire A, Al-Rayess M, Rothman D, Fayad P, Brass L, Shulman R, Prichard J. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology 1992, 42: 1349-54. PMID: 1620345, DOI: 10.1212/wnl.42.7.1349.Peer-Reviewed Original ResearchConceptsCells/mm2Foamy macrophagesElevation of lactateGlial densityNeuropathologic examinationBrain macrophagesHuman strokeHistopathology correlateMacrophage densityInfarctsHigh lactateHistopathologic sectionsStrokeLactate concentrationMedial marginMacrophagesLactate signalMonthsLactate poolWeeksLactateCellular localizationMetabolic turnoverMagnetic resonanceMagnetic resonance spectroscopyProton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients.
Graham G, Blamire A, Howseman A, Rothman D, Fayad P, Brass L, Petroff O, Shulman R, Prichard J. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 1992, 23: 333-340. PMID: 1542892, DOI: 10.1161/01.str.23.3.333.Peer-Reviewed Original ResearchConceptsProton magnetic resonance spectroscopyStroke patientsCerebral lactateDeep cerebral infarctsElevated cerebral lactateSmall subcortical infarctsCortical stroke patientsN-acetylaspartate levelsLong-term elevationCerebral infarctsCortical strokeOngoing ischemiaSymptom onsetBrain lactateElevated lactateInitial insultSubcortical infarctsN-acetylaspartateInfarct regionLesion onsetMagnetic resonance spectroscopyInfarctsPatientsFirst weekStroke