2002
Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in Epilepsy
Petroff O, Pan J, Rothman D. Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in Epilepsy. Epilepsia 2002, 43: 40-50. DOI: 10.1046/j.1528-1157.2002.043s1040.x.Peer-Reviewed Original ResearchCerebral electrical activityGlutamate-glutamine cycleGABA synthesisGABA levelsRefractory complex partial seizuresOccipital GABA levelsLower GABA levelsCerebral energy stateComplex partial seizuresElectrical activityKetone body metabolismΓ-aminobutyric acid (GABA) metabolismHuman visual cortexCerebral excitabilityGlutamate reuptakePartial seizuresRefractory epilepsyGABAergic neuronsKetogenic dietBrain metabolismCortical excitabilitySynaptic glutamateBrain glutamateMyoclonic epilepsyNeurotransmitter pool
2000
Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis
Pan J, Rothman D, Behar K, Stein D, Hetherington H. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1502-1507. PMID: 11043913, DOI: 10.1097/00004647-200010000-00012.Peer-Reviewed Original ResearchConceptsBHB levelsPlasma BHB levelsField magnetic resonance spectroscopyHigh-field magnetic resonance spectroscopyBrain lactateKetogenic dietCalcarine fissureNonfasted stateOccipital lobeHealthy adultsLactate increaseThird dayΒ-hydroxybutyrateKetosisBHB concentrationsBrainBHBGlucose phosphorylationLactate oxidationMagnetic resonance spectroscopy