2001
Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy
Chase J, Rothman D, Shulman R. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy. AJP Endocrinology And Metabolism 2001, 280: e598-e607. PMID: 11254467, DOI: 10.1152/ajpendo.2001.280.4.e598.Peer-Reviewed Original ResearchConceptsGlycogen synthesisGlycogen synthesis pathwayInsulin-stimulated muscle glycogen synthesisMetabolic control analysisMuscle glycogen synthesisGlycogen synthaseSynthesis pathwayGlycogen synthesis rateFlux controlGSaseHyperglycemic glucose concentrationsSynthesis rateControl coefficientsHexokinaseRat gastrocnemius muscleRelative contributionNMR spectroscopyGlycolysisSynthasePathway
1996
Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.
Shulman R, Rothman D. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7491-7495. PMID: 8755501, PMCID: PMC38772, DOI: 10.1073/pnas.93.15.7491.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthaseGlycogen synthesisGlucose transportMuscle glycogen synthaseAllosteric activationMetabolic control analysisMetabolic homeostasisPhosphorylationGlycogenic fluxEnzymatic phosphorylationHexokinase stepGSaseMuscle cellsHomeostasisFractional activityMuscle glycogen synthesisSynthaseConcentrations of G6PG6P concentrationActivityEnzymeMechanismRoleHexokinase