2002
Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in Epilepsy
Petroff O, Pan J, Rothman D. Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in Epilepsy. Epilepsia 2002, 43: 40-50. DOI: 10.1046/j.1528-1157.2002.043s1040.x.Peer-Reviewed Original ResearchCerebral electrical activityGlutamate-glutamine cycleGABA synthesisGABA levelsRefractory complex partial seizuresOccipital GABA levelsLower GABA levelsCerebral energy stateComplex partial seizuresElectrical activityKetone body metabolismΓ-aminobutyric acid (GABA) metabolismHuman visual cortexCerebral excitabilityGlutamate reuptakePartial seizuresRefractory epilepsyGABAergic neuronsKetogenic dietBrain metabolismCortical excitabilitySynaptic glutamateBrain glutamateMyoclonic epilepsyNeurotransmitter pool
1998
Measuring human brain GABA in vivo
Petroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidGABA concentrationSeizure controlDaily doseRelease of GABACerebrospinal fluid GABA concentrationsGABA synthesisImproved seizure controlComplex partial seizuresPoor seizure controlTraditional antiepileptic drugsSingle oral doseEffects of vigabatrinElevated CSFImportant protective mechanismPartial seizuresOral doseSeizure disorderAntiepileptic drugsNonvesicular releaseSeizure activityGABA levelsTransporter reversalVigabatrin
1997
496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy
Behar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.Peer-Reviewed Original Research
1996
Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy
Petroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.Peer-Reviewed Original ResearchConceptsBrain GABA contentImproved seizure controlBrain GABA levelsSeizure controlVigabatrin treatmentGABA levelsDaily doseAntiepileptic drugsOccipital lobeBrain gamma-aminobutyric acid (GABA) concentrationsGABA concentrationHuman brain GABA levelsGABA contentGamma-aminobutyric acid concentrationΓ-aminobutyric acid (GABA) levelsComplex partial seizuresNovel antiepileptic drugBrain GABA concentrationsSeizure frequencyPartial seizuresVigabatrin therapySustained elevationHuman occipital lobeGABA synthesisAcid levelsLow brain GABA level is associated with poor seizure control
Petroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.Peer-Reviewed Original ResearchConceptsLower GABA levelsBrain GABA levelsLower brain GABA levelsPoor seizure controlGABA levelsSeizure controlRecent seizuresGamma-aminobutyric acid concentrationComplex partial seizuresPartial seizuresEpileptic syndromesEpileptic focusOccipital lobeCerebrospinal fluidPatientsSeizuresSignificant associationMagnetic resonanceVivo measurementsSurface coilLevelsEpilepsySyndromeGABAAcid concentrationHuman brain GABA levels rise rapidly after initiation of vigabatrin therapy
Petroff O, Rothman D, Behar K, Collins T, Mattson R. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 1996, 47: 1567-1571.. PMID: 8960747, DOI: 10.1212/wnl.47.6.1567.Peer-Reviewed Original ResearchConceptsBrain GABA levelsBrain GABASingle oral doseOral doseGABA levelsSide effectsHuman brain GABA levelsEffective antiepileptic medicationsHours of administrationAntiepileptic medicationsVigabatrin therapyDay dosingIntractable epilepsySerial measurementsOccipital cortexVigabatrinDay 8Day 5GABAGABA transaminasePatientsDoseNext dayHuman brainMagnetic resonance spectroscopyHuman brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose
Petroff O, Rothman D, Behar K, Mattson R. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology 1996, 46: 1459-1463. PMID: 8628502, DOI: 10.1212/wnl.46.5.1459.Peer-Reviewed Original ResearchThe effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy
Petroff O, Rothman D, Behar K, Lamoureux D, Mattson R. The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. Annals Of Neurology 1996, 39: 95-99. PMID: 8572673, DOI: 10.1002/ana.410390114.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA levelsGABA levelsHuman brain GABA levelsBrain gamma-aminobutyric acidHigh-dose gabapentinAntiepileptic drug treatmentEffect of gabapentinPartial epilepsy patientsTreatment of epilepsyMechanism of actionAdjunctive therapyStandard dosesDrug treatmentEpilepsy patientsOccipital cortexGabapentinPatientsClinical useEpilepsyHuman brainMagnetic resonanceTreatmentMagnetic resonance spectroscopyVivo measurements
1995
Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain
Petroff O, Rothman D, Behar K, Mattson R. Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain. Epilepsia 1995, 36: 457-464. PMID: 7614922, DOI: 10.1111/j.1528-1157.1995.tb00486.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA levelsMumol/Antiepileptic drugsOccipital GABA levelsEffective antiepileptic drugEffects of vigabatrinStandard medicationStandard doseΓ-aminobutyric acidHealthy subjectsEpileptic patientsVigabatrinPatientsGABA transaminaseHuman cerebrumNoninvasive measurementHuman brainBrainGlutamateInitial observationsMedicationsCerebrumLevelsDoseVigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurologica Scandinavica. Supplementum 1995, 92: 27-30. PMID: 7495186, DOI: 10.1111/j.1600-0404.1995.tb00496.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain GABA levelsGABA levelsBrain concentrationsNerve terminalsAdministration of vigabatrinClear dose-response relationshipLevels of GABAPartial epileptic seizuresAnti-epilepsy drugsPresynaptic nerve terminalsDose-response relationshipConcentration of GABASecondary generalizationClinical effectsClinical outcomesVigabatrin administrationClinical trialsPatient responseClinical studiesSynaptic transmissionBaseline valuesOptimal doseVigabatrin levelsVigabatrinEpileptic seizures
1994
Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy. Epilepsia 1994, 35: s29-s32. PMID: 8039467, DOI: 10.1111/j.1528-1157.1994.tb05963.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsHuman brain GABA levelsGeneralized tonic-clonic seizuresTonic-clonic seizuresGamma-aminobutyric acid transaminaseNew antiepileptic drugsElevated brain GABA levelsTimes control valuesLong-term trialsDaily dosageAntiepileptic drugsClinical effectsGABA elevationCerebrospinal fluidSide effectsMagnetic resonance spectroscopyControl valuesIrreversible substrateResonance spectroscopyFirst studyDosageConcentrations 2VigabatrinSeizures