2012
Predictors of stunting, wasting and underweight among Tanzanian children born to HIV-infected women
McDonald CM, Kupka R, Manji KP, Okuma J, Bosch RJ, Aboud S, Kisenge R, Spiegelman D, Fawzi WW, Duggan CP. Predictors of stunting, wasting and underweight among Tanzanian children born to HIV-infected women. European Journal Of Clinical Nutrition 2012, 66: 1265-1276. PMID: 23031850, PMCID: PMC3491141, DOI: 10.1038/ejcn.2012.136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBody HeightBody WeightDouble-Blind MethodEducational StatusFemaleGrowth DisordersHIV InfectionsHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureInfectious Disease Transmission, VerticalMaleMalnutritionPremature BirthPrevalenceProportional Hazards ModelsReference ValuesSex FactorsSocioeconomic FactorsTanzaniaThinnessWasting SyndromeYoung AdultConceptsBirth weightFirst episodeTanzanian childrenMultivariate Cox proportional hazards methodMaternal educationLow infant birth weightCox proportional hazards methodDevelopment of undernutritionInfant birth weightLow Apgar scoreModifiable risk factorsLow birth weightChild HIV infectionHuman immunodeficiency virusPredictors of stuntingRisk of undernutritionProportional hazards methodsLow maternal educationWeeks of ageMorbidity historiesApgar scoreChild transmissionMedian durationPreterm infantsHIV infection
2005
Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-score
2004
Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy
Mwamburi DM, Wilson IB, Jacobson DL, Spiegelman D, Gorbach SL, Knox TA, Wanke CA. Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy. Clinical Infectious Diseases 2004, 40: 167-173. PMID: 15614708, DOI: 10.1086/426591.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyVirus loadBody weightAntiretroviral therapyHIV infectionWeight changeStudy visitHuman immunodeficiency virus RNA loadHighly Active Antiretroviral TherapyAbsence of HAARTProspective cohort studyCell count decreaseVirus RNA loadTime of enrollmentStudy intervalRepeated-measures analysisHIV loadHAART useCohort studyRNA loadHAARTPatientsEligible sampleCell countCount decreaseChanges in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men
Koh-Banerjee P, Wang Y, Hu FB, Spiegelman D, Willett WC, Rimm EB. Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men. American Journal Of Epidemiology 2004, 159: 1150-1159. PMID: 15191932, DOI: 10.1093/aje/kwh167.Peer-Reviewed Original ResearchConceptsRisk of diabetesBody fat distributionFat distributionWeight gainBody weightHealth Professionals FollowCases of diabetesWaist gainClinical diabetesProfessionals FollowWaist circumferenceHip circumferenceRisk factorsSubsequent riskUS menDiabetesAbdominal fatWeight changeHip girthMenRiskCircumferenceWaistPercentPrevious studiesFactors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
Knight EL, Verhave JC, Spiegelman D, Hillege HL, De Zeeuw D, Curhan GC, De Jong PE. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney International 2004, 65: 1416-1421. PMID: 15086483, DOI: 10.1111/j.1523-1755.2004.00517.x.Peer-Reviewed Original ResearchConceptsSerum cystatin C levelsCystatin C levelsSerum creatinine levelsSerum cystatin CRenal functionCreatinine levelsCreatinine clearanceCystatin CSerum creatininePartial Spearman correlationsC levelsCigarette smokingHigh serum C-reactive protein levelsHigher serum cystatin C levelsSerum C-reactive protein levelsC-reactive protein levelsSerum CRP levelsCurrent cigarette smokingRenal function measurementsSpearman correlationCross-sectional studyYears of ageCRP levelsMultivariate linear regression modelMale gender
2003
Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Colditz GA, Willett WC. Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1153-8. PMID: 14652274.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer riskHealth Study IIGlycemic loadCarbohydrate intakeCancer riskBreast cancerGlycemic indexDietary carbohydrateRelative riskFiber intakeNurses' Health Study IIMultivariate relative riskCorresponding relative risksFood frequency questionnaireInvasive breast cancerDietary carbohydrate intakeEarly adult lifeYoung adult womenPremenopausal womenFrequency questionnaireLean womenOverall cohortOverweight womenMass indexA Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumption
2002
Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection
Wilson I, Jacobson D, Roubenoff R, Spiegelman D, Knox T, Gorbach S. Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection. HIV Medicine 2002, 3: 263-270. PMID: 12444944, DOI: 10.1046/j.1468-1293.2002.00122.x.Peer-Reviewed Original ResearchConceptsTotal body weightSelf-reported physical functioningPhysical functioningHIV infectionBody weightRelationship of changesCells/ micro l.Mean CD4 countHIV-positive personsMain outcome measuresLean body massLongitudinal analysisCD4 countCohort studyPositive personsOutcome measuresHealthy personsBody compositionPatientsStudy designWeight lossMicro l.InfectionWomenHealthy livingRole of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff R, Grinspoon S, Skolnik PR, Tchetgen E, Abad L, Spiegelman D, Knox T, Gorbach S. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. AJP Endocrinology And Metabolism 2002, 283: e138-e145. PMID: 12067854, DOI: 10.1152/ajpendo.00426.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBody CompositionBody WeightCD4 Lymphocyte CountCytokinesEnergy MetabolismFollow-Up StudiesHIV InfectionsHIV Wasting SyndromeHumansInterleukin-1Linear ModelsLongitudinal StudiesMaleMiddle AgedNutritional StatusRestTestosteroneThinnessTumor Necrosis Factor-alphaViral LoadConceptsLBM lossPeripheral blood mononuclear cellsIL-1 beta productionWeight lossActive antiretroviral therapyCohort of patientsSerum free testosteroneBlood mononuclear cellsInadequate dietary intakeOngoing cohort studyCytokine tumor necrosisRole of cytokinesIL-1 betaTNF-alpha productionInterleukin-1 betaMo of observationLean body massKcal/dayAntiretroviral therapyCohort studyFree testosteroneHIV infectionIndependent predictorsCytokine productionMononuclear cellsDemographic, family, and occupational characteristics associated with major depression: the Harvard study of moods and cycles
Harlow BL, Cohen LS, Otto MW, Liberman RF, Spiegelman D, Cramer DW. Demographic, family, and occupational characteristics associated with major depression: the Harvard study of moods and cycles. Acta Psychiatrica Scandinavica 2002, 105: 209-217. PMID: 11939975, DOI: 10.1034/j.1600-0447.2002.1o102.x.Peer-Reviewed Original ResearchConceptsMajor depressionNon-depressed womenStructured Clinical InterviewHistory of depressionCommunity-based samplePast major depressionOccupational characteristicsStudy enrollmentDepressed womenClinical InterviewDSM-IVAge 18Past depressionWomenDepressionDemographic differencesHarvard StudySibship sizeNutrient intake and body weight in a large HIV cohort that includes women and minorities
WOODS MN, SPIEGELMAN D, Knox TA, FORRESTER JE, CONNORS JL, SKINNER SC, Silva M, KIM JH, GORBACH SL. Nutrient intake and body weight in a large HIV cohort that includes women and minorities. Journal Of The Academy Of Nutrition And Dietetics 2002, 102: 203-211. PMID: 11846114, DOI: 10.1016/s0002-8223(02)90049-0.Peer-Reviewed Original ResearchConceptsVitamin/mineral supplementsNutrient intakeMicronutrient intakeBaseline nutrient intakeLarge HIV cohortCD4 cell countCD4 lymphocyte countHIV-positive populationBody mass indexInadequate nutrient intakeStudy sampleNHANES III dataWilcoxon rank sum testCubic spline modelsMineral supplementsRank sum testHIV cohortLymphocyte countSpearman correlation coefficientMass indexProspective studyFood recordsMedian intakeDietary intakeNutritional intakeVitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth
Villamor E, Mbise R, Spiegelman D, Hertzmark E, Fataki M, Peterson KE, Ndossi G, Fawzi WW. Vitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth. Pediatrics 2002, 109: e6-e6. PMID: 11773574, DOI: 10.1542/peds.109.1.e6.Peer-Reviewed Original ResearchConceptsMid-upper arm circumferenceMonths of ageVitamin A supplementsPersistent diarrheaHIV infectionRespiratory infectionsVitamin AArm circumferenceHIV statusStudy clinicTreatment armsA supplementsHigher mid-upper arm circumferenceHuman immunodeficiency virus (HIV) infectionInfectious diseasesAdverse effectsLow arm circumferenceEpisodes of infectionImmunodeficiency virus infectionDay of admissionIU vitamin APrevalence of vitaminChild growthConfidence intervalsSeverity of diarrhea
2001
Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria. American Journal Of Epidemiology 2001, 154: 1107-1112. PMID: 11744515, DOI: 10.1093/aje/154.12.1107.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBody Mass IndexBody WeightCholesterol, HDLCohort StudiesCross-Sectional StudiesDiet SurveysDietary FatsDietary FiberDietary ProteinsEnergy IntakeExerciseFastingFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRegression AnalysisReproducibility of ResultsSmokingSurveys and QuestionnairesTriglyceridesConceptsTotal fat intakeFood frequency questionnaireFat intakeTriglyceride levelsFrequency questionnaireDietary fatSemiquantitative food frequency questionnaireHealth Professionals FollowBody mass indexHigh fat intakePlasma lipid levelsMetabolic studiesIntake of proteinCross-sectional analysisProfessionals FollowOverweight menMass indexInverse associationLipid levelsPhysical activityBlood specimensAlcohol consumptionSpecific biomarkersIntakeMultiple regression analysisWeight and body composition in a cohort of HIV-positive men and women
Forrester J, Spiegelman D, Woods M, Knox T, Fauntleroy J, Gorbach S. Weight and body composition in a cohort of HIV-positive men and women. Public Health Nutrition 2001, 4: 743-747. PMID: 11415480, DOI: 10.1079/phn200099.Peer-Reviewed Original ResearchDietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men
Chu N, Stampfer M, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. International Journal Of Obesity 2001, 25: 106-114. PMID: 11244465, DOI: 10.1038/sj.ijo.0801468.Peer-Reviewed Original ResearchConceptsBody mass indexPlasma leptin concentrationsLow plasma leptin concentrationsBody fat massLeptin concentrationsPhysical activityNormal weightOverweight menFat intakeLifestyle factorsFat massBlood samplesConfounding variablesWeight gainMonounsaturated fat intakeY weight gainRecent prospective studiesVenous blood samplesCurrent smokingObese menCholesterol intakeObese subjectsMass indexPlasma leptinProspective study
2000
Body Composition and Dietary Intake in Relation to Drug Abuse in a Cohort of HIV-Positive Persons
Forrester J, Woods M, Knox T, Spiegelman D, Skinner S, Gorbach S. Body Composition and Dietary Intake in Relation to Drug Abuse in a Cohort of HIV-Positive Persons. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 25: s43-s48. PMID: 11126426, DOI: 10.1097/00042560-200010001-00007.Peer-Reviewed Original ResearchConceptsBody mass indexIntravenous drug usersBody compositionDrug usersEnergy intakeDietary intakeFat massCurrent intravenous drug usersPast intravenous drug usersDrug abuseSelf-reported energy intakeHIV-positive personsHigher energy intakeBioelectrical impedance analysisCross-sectional analysisDrug use categoriesDrug use groupHIV infectionMass indexFood recordsDietary dataNonintravenous drugsNutritional statusIntakeWomenPooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ. Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk. American Journal Of Epidemiology 2000, 152: 514-527. PMID: 10997541, DOI: 10.1093/aje/152.6.514.Peer-Reviewed Original ResearchConceptsBody mass indexProspective cohort studyPostmenopausal womenRelative riskPremenopausal womenBreast cancerRisk factorsCohort studyIncident invasive breast cancer casesBreast cancer risk factorsInvasive breast cancer casesIndependent risk factorPooled relative riskPostmenopausal breast cancerCancer risk factorsBreast cancer variesBreast cancer riskBreast cancer casesMenopausal statusCancer variesMass indexAnthropometric indicesCancer casesCancer riskWeight controlRelation of lean body mass to health-related quality of life in persons with HIV.
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of lean body mass to health-related quality of life in persons with HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-46. PMID: 10935689, DOI: 10.1097/00126334-200006010-00008.Peer-Reviewed Original ResearchConceptsGeneral health perceptionPhysical functionHealth-related qualityLean body massHigher lean body massHealth perceptionAssociated with better physical functionClinical impact of interventionsHealth-related quality of lifeDiverse population of personsBioimpedance analysisPatient self-reportBody massImpact of interventionsPopulation of personsCross-sectional analysisQuality of lifeIncreased LBMSelf-reportDiverse populationsEnergy/fatigueMultivariate modelHIVCD4 countHIV infectionRelation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-146. DOI: 10.1097/00042560-200006010-00008.Peer-Reviewed Original ResearchConceptsLean body massHigher lean body massGeneral health perceptionEnergy/fatiguePhysical functioningHealth perceptionBetter general health perceptionBioimpedance analysisDesign Cross-sectional analysisMeasures of HRQLHealth-related qualityBody massLast monthBetter physical functioningQuality of lifeCross-sectional analysisCD4 countHIV infectionMean ageClinical impactMultivariable modelHIVCells/Number of daysWomen
1998
The effect of protease inhibitors on weight and body composition in HIV-infected patients
Silva M, Skolnik P, Gorbach S, Spiegelman D, Wilson I, Fernández-DiFranco M, Knox T. The effect of protease inhibitors on weight and body composition in HIV-infected patients. AIDS 1998, 12: 1645-1651. PMID: 9764784, DOI: 10.1097/00002030-199813000-00012.Peer-Reviewed Original ResearchConceptsLean body massPI therapyHIV infectionWeight gainViral loadPhysical functioningHealth perceptionBody compositionCurrent health perceptionsActive antiretroviral therapyPI treatmentProtease inhibitor therapyBody mass indexGreater weight gainHuman growth hormoneAntiretroviral therapyHIV cohortBody massInhibitor therapyMass indexOptimal therapyFat massAnabolic stimuliPatientsGrowth hormone