2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeIntervention
2020
Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini
Boeke C, Khan S, Walsh F, Hettema A, Lejeune C, Spiegelman D, Okello V, Harwell J, Mazibuko S, Bärnighausen T. Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini. HIV Medicine 2020, 22: 54-59. PMID: 32876360, DOI: 10.1111/hiv.12941.Peer-Reviewed Original ResearchConceptsBody mass indexStepped-wedge trialDisease progressionCD4 countSevere diseaseMultivariate Cox proportional hazards modelWorld Health Organization stageCox proportional hazards modelHIV disease progressionMorbidity/mortalityCells/Proportional hazards modelLower ratesIncident tuberculosisCD4 declineMass indexUniversal testHealth facilitiesBaseline valuesHazards modelHealth outcomesCrowded hospitalsWeight lossProgressionHIV
2005
Increasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003
Tang AM, Jacobson DL, Spiegelman D, Knox TA, Wanke C. Increasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 70-76. PMID: 16123685, DOI: 10.1097/01.qai.0000159627.54149.2e.Peer-Reviewed Original ResearchConceptsCohort of HIVUnintentional weight lossWeight lossAntiretroviral therapyBody compositionLow CD4 cell countsHigher HIV viral loadHigher body mass indexCare of HIVHealthy Living cohortActive antiretroviral therapyCD4 cell countCombination antiretroviral therapyHIV viral loadBody mass indexRisk of deathPresence of diarrheaFederal poverty levelLiving cohortHIV infectionMass indexMost AIDSOpportunistic infectionsViral loadPatient population
2004
Breastfeeding and maternal HIV-1 disease progression and mortality
Sedgh G, Spiegelman D, Larsen U, Msamanga G, Fawzi WW. Breastfeeding and maternal HIV-1 disease progression and mortality. AIDS 2004, 18: 1043-1049. PMID: 15096808, DOI: 10.1097/00002030-200404300-00013.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionCD4 cell countDisease progressionCell countHigher CD4 cell countsLow CD4 cell countsCox proportional hazards modelHealth of HIVCohort study designExcessive weight lossProportional hazards modelPartial breastfeedingRelative riskHazards modelInsufficient evidenceBreastfeedingMultivariate analysisStudy designWeight lossWomenProgressionDar es SalaamHIVDeathAssociation
2003
Difficulty Swallowing and Lack of Receipt of Highly Active Antiretroviral Therapy Predict Acute Weight Loss in Human Immunodeficiency Virus Disease
Jacobson DL, Bica I, Knox TA, Wanke C, Tchetgen E, Spiegelman D, Silva M, Gorbach S, Wilson IB. Difficulty Swallowing and Lack of Receipt of Highly Active Antiretroviral Therapy Predict Acute Weight Loss in Human Immunodeficiency Virus Disease. Clinical Infectious Diseases 2003, 37: 1349-1356. PMID: 14583869, DOI: 10.1086/379072.Peer-Reviewed Original ResearchConceptsAcute weight lossHuman immunodeficiency virus (HIV) diseaseOral symptomsWeight lossLack of receiptActive antiretroviral therapyUpper respiratory symptomsVirus diseaseTrouble swallowingAbdominal painAntiretroviral therapyRespiratory symptomsDifficulty swallowingNutrient malabsorptionSkin symptomsCommon symptomsRecent symptomsCaloric intakeSymptom complexSymptomsWeight changeDiarrheaMetabolic needsSwallowingDisease
2002
Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3
Forrester JE, Spiegelman D, Tchetgen E, Knox TA, Gorbach SL. Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1428-1434. PMID: 12450913, DOI: 10.1093/ajcn/76.6.1428.Peer-Reviewed Original ResearchWeight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy
Tang AM, Forrester J, Spiegelman D, Knox TA, Tchetgen E, Gorbach SL. Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 230-236. PMID: 12394802, DOI: 10.1097/01.qai.0000026514.98625.8f.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyWeight lossAntiretroviral therapyHAART useIndependent predictorsPrevious visitHighly Active Antiretroviral TherapyHealthy Living StudyCD4 cell countHIV-positive patientsHIV-positive participantsBody mass indexStrong independent predictorFurther prognostic valueProportional hazards modelBioelectrical impedance analysisFour- to sixfold increaseImportant comorbidityMass indexPrognostic valuePotential confoundersRelative riskStudy populationLiving StudyHazards modelChanges in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection
Wilson I, Jacobson D, Roubenoff R, Spiegelman D, Knox T, Gorbach S. Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection. HIV Medicine 2002, 3: 263-270. PMID: 12444944, DOI: 10.1046/j.1468-1293.2002.00122.x.Peer-Reviewed Original ResearchConceptsTotal body weightSelf-reported physical functioningPhysical functioningHIV infectionBody weightRelationship of changesCells/ micro l.Mean CD4 countHIV-positive personsMain outcome measuresLean body massLongitudinal analysisCD4 countCohort studyPositive personsOutcome measuresHealthy personsBody compositionPatientsStudy designWeight lossMicro l.InfectionWomenHealthy livingRole of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff R, Grinspoon S, Skolnik PR, Tchetgen E, Abad L, Spiegelman D, Knox T, Gorbach S. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. AJP Endocrinology And Metabolism 2002, 283: e138-e145. PMID: 12067854, DOI: 10.1152/ajpendo.00426.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBody CompositionBody WeightCD4 Lymphocyte CountCytokinesEnergy MetabolismFollow-Up StudiesHIV InfectionsHIV Wasting SyndromeHumansInterleukin-1Linear ModelsLongitudinal StudiesMaleMiddle AgedNutritional StatusRestTestosteroneThinnessTumor Necrosis Factor-alphaViral LoadConceptsLBM lossPeripheral blood mononuclear cellsIL-1 beta productionWeight lossActive antiretroviral therapyCohort of patientsSerum free testosteroneBlood mononuclear cellsInadequate dietary intakeOngoing cohort studyCytokine tumor necrosisRole of cytokinesIL-1 betaTNF-alpha productionInterleukin-1 betaMo of observationLean body massKcal/dayAntiretroviral therapyCohort studyFree testosteroneHIV infectionIndependent predictorsCytokine productionMononuclear cells
2001
The correlates of dietary intake among HIV-positive adults 1 , 2 , 3
Kim J, Spiegelman D, Rimm E, Gorbach S. The correlates of dietary intake among HIV-positive adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 852-861. PMID: 11722969, DOI: 10.1093/ajcn/74.6.852.Peer-Reviewed Original ResearchConceptsHigher energy intakeDietary intakeEnergy intakeHIV infectionClinical outcomesDietary adequacyAdverse clinical outcomesAbsence of nauseaInadequate dietary intakeInadequate protein intakeInadequate energy intakeInjection drug usersCross-sectional studyStudy cohortFemale sexDiet recordsReduced appetiteDietary inadequacyStudy populationProtein intakeDietary allowanceDrug usersDiverse cohortIntakeWeight lossRelationship of a large weight loss to long-term weight change among young and middle-aged US women
Field A, Wing R, Manson J, Spiegelman D, Willett W. Relationship of a large weight loss to long-term weight change among young and middle-aged US women. International Journal Of Obesity 2001, 25: 1113-1121. PMID: 11477495, DOI: 10.1038/sj.ijo.0801643.Peer-Reviewed Original ResearchConceptsHealth Study IIWeight lossPhysical activityNurses' Health Study IILong-term weight changeLong-term weight gainCategories of BMIBody mass indexLarge weight lossVigorous physical activityMiddle-aged womenSignificant weight lossSelf-reported weightDiagnosis of cancerMass indexWeight cyclingDietary intakeCardiovascular diseaseLess weightUS womenMost womenInactive peersBMIWeight gainStudy IIWeight and body composition in a cohort of HIV-positive men and women
Forrester J, Spiegelman D, Woods M, Knox T, Fauntleroy J, Gorbach S. Weight and body composition in a cohort of HIV-positive men and women. Public Health Nutrition 2001, 4: 743-747. PMID: 11415480, DOI: 10.1079/phn200099.Peer-Reviewed Original Research
2000
Adiposity and Mortality in Men
Baik I, Ascherio A, Rimm EB, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Adiposity and Mortality in Men. American Journal Of Epidemiology 2000, 152: 264-271. PMID: 10933273, DOI: 10.1093/aje/152.3.264.Peer-Reviewed Original ResearchConceptsBody mass indexRecent weight lossMeasures of adiposityCardiovascular diseaseGreater body mass indexWeight lossCardiovascular disease mortalityRisk of deathCancer mortality riskCause-specific mortalityExclusion of menLean menOverall mortalityWaist circumferenceMass indexDisease mortalityExcess mortalityRelative riskBody fatMortality riskUS menElevated riskOlder menHigh mortalityMortality
1999
Recreational Physical Activity and the Risk of Cholecystectomy in Women
Leitzmann M, Rimm E, Willett W, Spiegelman D, Grodstein F, Stampfer M, Colditz G, Giovannucci E. Recreational Physical Activity and the Risk of Cholecystectomy in Women. New England Journal Of Medicine 1999, 341: 777-784. PMID: 10477775, DOI: 10.1056/nejm199909093411101.Peer-Reviewed Original ResearchConceptsRisk of cholecystectomyRecreational physical activityMultivariate relative riskPhysical activityGallstone diseaseRelative riskSedentary behaviorHealth StudyBody weightCases of cholecystectomyRecent weight lossNurses' Health StudyYears of ageSymptomatic cholelithiasisDecreased riskLowest quintileRisk factorsCholecystectomyWeight lossWeight changeWomenDiseaseActivity levelsWeeksRisk
1998
Can behavioral risk factors explain the difference in body mass index between African-American and European-American women?
Holmes MD, Stampfer MJ, Wolf AM, Jones CP, Spiegelman D, Manson JE, Colditz GA. Can behavioral risk factors explain the difference in body mass index between African-American and European-American women? Ethnicity & Disease 1998, 8: 331-9. PMID: 9926903.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAfrican American womenEuropean American womenMass indexIntentional weight lossMeasurements of dietBehavioral risk factorsModifiable reasonsRisk factorsPhysical activityCalorie intakeFemale nursesAge 18Weight lossMultivariate determinantsWomenTelevision watchingMarital statusBehavioral factorsAfrican AmericansWeight differencesOccupation groupsAgeLinear regression