2003
Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men. Journal Of Nutrition 2003, 133: 3658-3663. PMID: 14608090, DOI: 10.1093/jn/133.11.3658.Peer-Reviewed Original ResearchConceptsPeripheral arterial disease riskCereal fiber intakeArterial disease riskPAD riskFiber intakeInverse associationDisease riskEarly coronary heart diseaseIncident PAD casesFood frequency questionnaireCoronary heart diseaseTotal fiber intakeOverall inverse associationDisease QuestionnaireFrequency questionnaireLowest quintileHeart diseaseCardiovascular diseaseFamily historyPhysical activityPAD casesAlcohol consumptionEnergy intakeIntakeRisk
2002
The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Research 2002, 62: 1045-9. PMID: 11861380.Peer-Reviewed Original ResearchConceptsFirst-degree family historyBreast cancer riskHealth Study cohortAndrogen receptorBreast cancerCancer riskFamily historyAR genotypeCaucasian womenHormone levelsHealth StudyNurses' Health Study cohortBreast cancer risk factorsEndogenous steroid hormone levelsNurses' Health StudyCancer risk factorsPostmenopausal Caucasian womenCase-control studyAndrogen receptor genotypeAndrogen receptor CAGAndrogen receptor allelesSteroid hormone levelsShort alleleLong alleleSignificant positive association
2000
Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily history
1998
Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer
Yoshizawa K, Willett W, Morris S, Stampfer M, Spiegelman D, Rimm E, Giovannucci E. Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer. Journal Of The National Cancer Institute 1998, 90: 1219-1224. PMID: 9719083, DOI: 10.1093/jnci/90.16.1219.Peer-Reviewed Original ResearchConceptsAdvanced prostate cancerProstate cancerProspective studyControl subjectsHealth professionalsSelenium levelsMale health professionalsFurther prospective studiesBody mass indexLong-term selenium intakeSelenium intakeCase-control designHigh selenium intakeLycopene intakeCalcium intakeMass indexPrediagnostic levelsRandomized trialsSmoking statusFat intakeIntervention trialsFamily historyCohort membersDaily supplementToenail clippings
1997
A Prospective Study of Pregravid Determinants of Gestational Diabetes Mellitus
Solomon CG, Willett WC, Carey VJ, Rich-Edwards J, Hunter DJ, Colditz GA, Stampfer MJ, Speizer FE, Spiegelman D, Manson JE. A Prospective Study of Pregravid Determinants of Gestational Diabetes Mellitus. JAMA 1997, 278: 1078-1083. PMID: 9315766, DOI: 10.1001/jama.1997.03550130052036.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexPregravid body mass indexHealth Study IIDiabetes mellitusGDM riskWeight gainMaternal ageRisk factorsRelative riskFamily historyRisk of GDMNurses' Health Study IIPrevious gestational diabetes mellitusHigher body mass indexNoninsulin-dependent diabetes mellitusGDM risk factorsProspective cohort studyMedical record reviewEarly adulthoodPossible preventive strategiesIdentification of womenSubstantial weight gainAdvanced maternal ageGreater weight gainDietary Fiber, Glycemic Load, and Risk of NIDDM in Men
Salmerón J, Ascherio A, Rimm E, Colditz G, Spiegelman D, Jenkins D, Stampfer M, Wing A, Willett W. Dietary Fiber, Glycemic Load, and Risk of NIDDM in Men. Diabetes Care 1997, 20: 545-550. PMID: 9096978, DOI: 10.2337/diacare.20.4.545.Peer-Reviewed Original ResearchConceptsRisk of NIDDMHigh glycemic loadGlycemic loadCereal fiberRelative riskHigher cereal fiber intakeSemiquantitative food frequency questionnaireCereal fiber intakeLarge glycemic responseDietary glycemic indexFood frequency questionnaireIncidence of NIDDMIntake of carbohydratesTotal energy intakeLow glycemic loadYears of ageDietary fiberFrequency questionnaireIncident casesLowest quintileCardiovascular diseaseFamily historyFiber intakeNIDDMPhysical activityA Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women
Chasan-Taber L, Willett W, Stampfer M, Hunter D, Colditz G, Spiegelman D, Manson J. A Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women. Diabetes Care 1997, 20: 330-335. PMID: 9051382, DOI: 10.2337/diacare.20.3.330.Peer-Reviewed Original ResearchConceptsOral contraceptivesRelative riskPast usersProspective studyModern oral contraceptivesU.S. female nursesMultivariate relative riskOral contraceptive useProspective cohort studyLarge prospective studiesLow absolute riskCoronary heart diseaseCurrent usersHistory of diagnosisDiagnosed diabetesCohort studyElevated cholesterolAlcohol intakeCigarette smokingIncident casesSymptomatic casesAbsolute riskExcess riskHeart diseaseFamily historyNon-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer
Hunter D, Spiegelman D, Adami H, van den Brandt P, Folsom A, Goldbohm R, Graham S, Howe G, Kushi L, Marshall J, Miller A, Speizer F, Willett W, Wolk A, Yaun S. Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes & Control 1997, 8: 49-56. PMID: 9051322, DOI: 10.1023/a:1018431104786.Peer-Reviewed Original ResearchConceptsBenign breast diseaseTotal fat intakeFat intakeBreast cancer riskRisk factorsBreast cancerBreast diseaseRelative riskCancer riskNon-dietary risk factorsEnergy-adjusted fat intakeMultivariate-adjusted riskFood frequency questionnaireDietary fat intakeAge-adjusted analysesCase-control studyNon-dietary factorsProspective studyMaternal historyLate menarcheHigher parityDietary fatFamily historyReproductive factorsEffect modifiers
1996
Birth weight and adult hypertension, diabetes mellitus, and obesity in US men.
Curhan G, Willett W, Rimm E, Spiegelman D, Ascherio A, Stampfer M. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996, 94: 3246-50. PMID: 8989136, DOI: 10.1161/01.cir.94.12.3246.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioAdult body mass indexLow birth weightBody mass indexDiabetes mellitusBirth weightAdult hypertensionMass indexOdds ratioChronic diseasesUS menChronic adult diseasesBirth weight categoriesDependent diabetes mellitusPrevalence of obesityRisk of hypertensionRisk of obesityHigh birth weightEarly life exposureCumulative incidenceLowest quintileMedical historyRisk factorsFamily historyLife exposureProspective study of oral contraceptives and hypertension among women in the United States.
Chasan-Taber L, Willett W, Manson J, Spiegelman D, Hunter D, Curhan G, Colditz G, Stampfer M. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 1996, 94: 483-9. PMID: 8759093, DOI: 10.1161/01.cir.94.3.483.Peer-Reviewed Original ResearchConceptsOral contraceptivesBody mass indexMass indexRelative riskFamily historyAge-adjusted relative riskPast usersHigh-dose pillsMultivariate relative riskOral contraceptive useProspective cohort studyRisk of hypertensionCoronary heart diseaseRisk of developmentLow-dose formulationsCurrent usersMicrograms estrogenHypertensive effectCohort studyEffect of ageBlood pressureAlcohol intakeCigarette smokingIncident casesProspective study
1994
Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk
Spiegelman D, Colditz GA, Hunter D, Hertzmark E. Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk. Journal Of The National Cancer Institute 1994, 86: 600-607. PMID: 8145275, DOI: 10.1093/jnci/86.8.600.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyIndividual breast cancer riskCancer riskBreast cancerHealth StudyGail et alAbsolute breast cancer riskPopulation-based studyMammography screening ratesExtensive family historyIndividual woman's riskPremenopausal womenAnnual screeningPrevention trialsScreening ratesRisk factorsCancer casesFamily historyTrial investigatorsStudy populationWoman's riskCancerPrevention effortsStudy period