FRS2α-dependent cell fate transition during endocardial cushion morphogenesis
Chen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental Biology 2019, 458: 88-97. PMID: 31669335, DOI: 10.1016/j.ydbio.2019.10.022.Peer-Reviewed Original ResearchConceptsCell fate transitionsFate transitionsAtrioventricular valve developmentInducible endothelial-specific deletionPivotal controllerEmbryonic developmentEndothelial-specific deletionFRS2αValve developmentEndocardial cushionsEndocardial cellsMesenchymal transitionMesenchymal cellsAV cushionsDefective maturationDevelopmental abnormalitiesDeletionAdult endothelium