2011
Bi‐allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia
Massaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P. Bi‐allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia. Pediatric Blood & Cancer 2011, 57: 516-519. PMID: 21538823, PMCID: PMC4517576, DOI: 10.1002/pbc.23156.Peer-Reviewed Original Research
2010
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. Journal Of Experimental Medicine 2010, 207: 1183-1195. PMID: 20457756, PMCID: PMC2882842, DOI: 10.1084/jem.20092215.Peer-Reviewed Original ResearchConceptsSmall ubiquitin-like modifier (SUMO) modificationImportant regulatory mechanismEmbryonic day 13.5Down-regulation correlatesFetal liverCre-loxP systemEmbryonic lethalityProtein functionDefinitive erythropoiesisGene promoterDNA bindingRegulatory mechanismsGene expressionGATA1SENP1Fetal liver cellsProtein analysisDay 13.5Global deletionProteinSubsequent erythropoiesisKnockout miceErythropoiesisLiver cellsDeSUMOylation
2009
Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture
Mahajan MC, Karmakar S, Newburger PE, Krause DS, Weissman SM. Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture. Experimental Hematology 2009, 37: 1143-1156.e3. PMID: 19607874, PMCID: PMC2997688, DOI: 10.1016/j.exphem.2009.07.001.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-GlobinsAntigens, CD34CCCTC-Binding FactorCells, CulturedChromatin Assembly and DisassemblyEnhancer Elements, GeneticErythroid Precursor CellsErythropoiesisErythropoietinGATA1 Transcription FactorGene Expression Regulation, DevelopmentalGlycophorinsHematopoietic Cell Growth FactorsHistonesHumansInsulator ElementsNF-E2 Transcription Factor, p45 SubunitProtein BindingRepressor ProteinsRNA Polymerase IITranscription FactorsConceptsAlpha-globin lociTranscription factor recruitmentChromatin structureGATA-1Transcription factorsErythroid differentiationGene expressionFactor recruitmentPol IIQuantitative polymerase chain reaction analysisAlpha-globin gene expressionKey erythroid transcription factorsErythroid transcription factorsNF-E2Chromatin immunoprecipitation-quantitative polymerase chain reaction analysisAlpha-globin genesUpstream activator sitesBeta-like genesPolymerase chain reaction analysisChain reaction analysisStages of erythropoiesisGlobin promoterDifferent differentiation stagesFactor CTCFHistone modifications