2017
Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration
Laneve P, Piacentini L, Casale AM, Capauto D, Gioia U, Cappucci U, Di Carlo V, Bozzoni I, Di Micco P, Morea V, Di Franco CA, Caffarelli E. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Scientific Reports 2017, 7: 41559. PMID: 28139767, PMCID: PMC5282483, DOI: 10.1038/srep41559.Peer-Reviewed Original ResearchConceptsEukaryotic RNA metabolismDrosophila nervous systemTDP-43-mediated neurodegenerationImportant biological processesNovel family memberUnique biochemical featuresEssential endoribonucleaseRibosome biogenesisDrosophila viabilityRNA metabolismPositive regulatorFunctional characterisationBiosynthetic enzymesRibonuclease familyGene productsBiological processesMolecular levelNervous system activityBiochemical featuresCholinergic circuitsPhenotypeViral replicationNervous systemImmature phenotypeFamily members
2015
DOF AFFECTING GERMINATION 2 is a positive regulator of light-mediated seed germination and is repressed by DOF AFFECTING GERMINATION 1
Santopolo S, Boccaccini A, Lorrai R, Ruta V, Capauto D, Minutello E, Serino G, Costantino P, Vittorioso P. DOF AFFECTING GERMINATION 2 is a positive regulator of light-mediated seed germination and is repressed by DOF AFFECTING GERMINATION 1. BMC Plant Biology 2015, 15: 72. PMID: 25850831, PMCID: PMC4355143, DOI: 10.1186/s12870-015-0453-1.Peer-Reviewed Original ResearchConceptsSeed germination processPositive regulatorSeed germinationGermination processSeed germination phenotypesChromatin immuno-precipitation analysisImmuno-precipitation analysisGERMINATION 1Mutant seedsGermination phenotypePhytochrome BMaster repressorGibberellin biosynthesisGermination capabilityGermination potentialGerminationRepressorMutantsSeedsOpposite rolesRegulatorEnvironmental factorsDAG2ExpressionRed light
2014
Independent and interactive effects of DOF affecting germination 1 (DAG1) and the Della proteins GA insensitive (GAI) and Repressor of ga1-3(RGA) in embryo development and seed germination
Boccaccini A, Santopolo S, Capauto D, Lorrai R, Minutello E, Belcram K, Palauqui JC, Costantino P, Vittorioso P. Independent and interactive effects of DOF affecting germination 1 (DAG1) and the Della proteins GA insensitive (GAI) and Repressor of ga1-3(RGA) in embryo development and seed germination. BMC Plant Biology 2014, 14: 200. PMID: 25064446, PMCID: PMC4222566, DOI: 10.1186/s12870-014-0200-z.Peer-Reviewed Original ResearchConceptsGA INSENSITIVESeed germinationEmbryo developmentDouble mutantGai-t6GERMINATION 1Mutant seedsGa1-3Germination pathwaySingle mutantsRepressorUnexpected involvementMutantsDistinct rolesGerminationGermination propertiesIndependent branchInteractive effectsGERMINATION1DAG1DormancyGenesSeedsPathwayInactivationThe DOF Protein DAG1 and the DELLA Protein GAI Cooperate in Negatively Regulating the AtGA3ox1 Gene
Boccaccini A, Santopolo S, Capauto D, Lorrai R, Minutello E, Serino G, Costantino P, Vittorioso P. The DOF Protein DAG1 and the DELLA Protein GAI Cooperate in Negatively Regulating the AtGA3ox1 Gene. Molecular Plant 2014, 7: 1486-1489. PMID: 24719470, DOI: 10.1093/mp/ssu046.Peer-Reviewed Original Research