2023
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Stiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.Peer-Reviewed Original ResearchCocaine use disorderUse disordersAddiction patternsMixed bipolar episodesLatent class analysisDSM-5 diagnosisPosttraumatic stress disorderAntisocial personality disorderPsA severityMedication useHigher PSAPSA subgroupsHigher oddsBipolar episodesStress disorderPersonality disorderDisordersSubgroupsAgeSexClass analysisParticipantsComorbiditiesDiseaseDiagnosis
2022
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorder
2015
Gene networks specific for innate immunity define post-traumatic stress disorder
Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O'Connor DT, Nievergelt CM, Woelk CH. Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 2015, 20: 1538-1545. PMID: 25754082, PMCID: PMC4565790, DOI: 10.1038/mp.2015.9.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPTSD developmentStress disorderExpression of genesDevelopment of PTSDEarly preventative measuresPeripheral blood leukocytesInnate immune responseProper wound healingProspective experimental designClinical indicatorsRNA-seq gene expressionHemostatic systemBlood leukocytesInnate immuneCausal pathophysiologyMechanisms of PTSDCo-regulated genesInnate immunityPrevious transcriptomic studiesTrauma exposureCo-expression modulesU.S. MarinesPreventative measuresWound healing
2014
Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study
Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr JB, Kremen WS, Investigators M, Baker D, Glatt S, Tsuang M. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology 2014, 51: 472-494. PMID: 25311155, PMCID: PMC4199086, DOI: 10.1016/j.psyneuen.2014.09.024.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPeripheral bloodBiomarker panelStress disorderPilot studyPeripheral blood biomarkersHigh-risk individualsPeripheral blood samplesPeripheral blood cellsExpression levelsDiagnostic biomarker panelGene expression levelsTrauma-exposed individualsBlood biomarkersBlood samplesGene expression biomarkersBiomarker profilesDiagnostic utilityBrain tissueDiagnostic panelBlood cellsBloodFull-length gene transcriptsBiomarkersDisorders