Day-to-day Relationships between Physical Activity and Sleep Characteristics among People with Heart Failure and Insomnia
Ash G, Jeon S, Conley S, Knies AK, Yaggi HK, Jacoby D, Hollenbeak CS, Linsky S, O’Connell M, Redeker NS. Day-to-day Relationships between Physical Activity and Sleep Characteristics among People with Heart Failure and Insomnia. Behavioral Sleep Medicine 2020, 19: 602-614. PMID: 33048589, PMCID: PMC8496686, DOI: 10.1080/15402002.2020.1824918.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAgedExerciseFemaleHeart FailureHumansMaleMiddle AgedRandomized Controlled Trials as TopicSleepSleep Initiation and Maintenance DisordersTime FactorsConceptsNext-day physical activityHeart failureTotal sleep timePhysical activityCounts/minuteSleep characteristicsSleep timeSleep variablesNYHA class IIAdvanced heart failureStable heart failureDaytime physical activityBody mass indexCommunity-dwelling adultsWrist actigraphy recordingsCognitive behavioral therapyNYHA classHF classMass indexSleep improvementActigraphy recordingsLong sleepBehavioral therapyClass IIInsomniaStudy Design and Rationale of EXPLORER-HCM
Ho CY, Olivotto I, Jacoby D, Lester SJ, Roe M, Wang A, Waldman CB, Zhang D, Sehnert AJ, Heitner SB. Study Design and Rationale of EXPLORER-HCM. Circulation Heart Failure 2020, 13: e006853. PMID: 32498620, DOI: 10.1161/circheartfailure.120.006853.Peer-Reviewed Original ResearchConceptsNew York Heart Association classLV outflow tract obstructionObstructive hypertrophic cardiomyopathyOutflow tract obstructionPeak oxygen consumptionEXPLORER-HCMTract obstructionAssociation classEnd pointExercise capacityNew York Heart Association functional class IIDynamic LV outflow tract obstructionKansas City Cardiomyopathy QuestionnaireLV outflow tract gradientSymptomatic obstructive hypertrophic cardiomyopathyUnexplained left ventricular hypertrophyOxygen consumptionExploratory end pointsFunctional class IIOutflow tract gradientPlacebo-controlled trialSecondary end pointsPhase 2 studyPhase 3 trialCurrent medical therapy