2015
Biologically active LIL proteins built with minimal chemical diversity
Heim EN, Marston JL, Federman RS, Edwards AP, Karabadzhak AG, Petti LM, Engelman DM, DiMaio D. Biologically active LIL proteins built with minimal chemical diversity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4717-e4725. PMID: 26261320, PMCID: PMC4553812, DOI: 10.1073/pnas.1514230112.Peer-Reviewed Original ResearchConceptsAmino acidsTransmembrane proteinSpecific biological activityPlatelet-derived growth factor β receptorArtificial transmembrane proteinsChemical diversityGrowth factor β receptorHydrophobic amino acidsLIL proteinsKnown proteinsIndividual amino acidsTransmembrane domainCellular contextDifferent amino acidsComplete mutagenesisMost proteinsBiological activityActive proteinSimple proteinSingle isoleucineSpecific sequencesProteinDiversityLeucineΒ receptor
1991
Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptor
Kulke R, DiMaio D. Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptor. Journal Of Virology 1991, 65: 4943-4949. PMID: 1651413, PMCID: PMC248956, DOI: 10.1128/jvi.65.9.4943-4949.1991.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, NorthernCell Transformation, ViralCloning, MolecularDeerDNAGene ExpressionGenes, ViralIn Vitro TechniquesMiceMolecular Sequence DataOncogene Proteins, ViralPapillomaviridaePlatelet-Derived Growth FactorReceptors, Cell SurfaceReceptors, Platelet-Derived Growth FactorRNA, ViralViral Structural ProteinsConceptsMouse C127 cellsE5 proteinC127 cellsE5 genePlatelet-derived growth factor beta receptorPDGF receptorBovine papillomavirus type 1 E5 proteinConstitutive tyrosine phosphorylationDNA synthesisGrowth factor beta receptorBovine papillomavirus type 1Platelet-derived growth factor receptorTransformation of fibroblastsPapillomavirus type 1Sequence similarityGrowth factor receptorTyrosine phosphorylationBiological activityShort regionFoci formationProteinFactor receptorReceptor formsB chainGrowth transformation
1987
Mutational analysis of open reading frame E4 of bovine papillomavirus type 1
Neary K, Horwitz B, DiMaio D. Mutational analysis of open reading frame E4 of bovine papillomavirus type 1. Journal Of Virology 1987, 61: 1248-1252. PMID: 3029420, PMCID: PMC254088, DOI: 10.1128/jvi.61.4.1248-1252.1987.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type 1Papillomavirus type 1E4 proteinLate gene expressionMouse C127 cellsAmino acid sequenceAcid sequenceExtrachromosomal plasmidsBiological activityC127 cellsMutational analysisGene expressionFoci formationORF E2ORFProteinViral DNAMutationsSoft agaroseCellsMutantsType 1Papilloma formationDNAPlasmid