2017
Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH
Rao JU, Coman D, Walsh JJ, Ali MM, Huang Y, Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH. Scientific Reports 2017, 7: 7865. PMID: 28801587, PMCID: PMC5554228, DOI: 10.1038/s41598-017-07609-7.Peer-Reviewed Original ResearchConceptsU251 tumorsTumor microenvironmentT2-weighted MRITherapeutic responseUntreated ratsTumor volumeRat brainTumor growthTherapeutic influenceGlioma growthPeritumoral regionRatsApoptosis inductionTumorsGliomasTumor corePhysiological readoutsExtracellular pHAcidic pHeTumor boundariesProliferationMicroenvironment
2016
Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy