2024
Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance
Marquina-Solis J, Feng L, Vandewyer E, Beets I, Hawk J, Colón-Ramos D, Yu J, Fox B, Schroeder F, Bargmann C. Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance. Cell Reports 2024, 43: 114042. PMID: 38573858, PMCID: PMC11063628, DOI: 10.1016/j.celrep.2024.114042.Peer-Reviewed Original ResearchConceptsFLP-1 neuropeptidesBacterium Pseudomonas aeruginosa PA14Pathogen avoidanceGrowth factor BNematode Caenorhabditis elegansC. elegansCaenorhabditis elegansAvoidance signalPathogen infectionFlp-1NeuropeptidePathogensNeuronsMultiple mechanismsMultiple neuronsInfectionNeuromodulationPromote recoveryFactor BAvoidance behaviorAVKPA14
2011
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
Christensen R, de la Torre-Ubieta L, Bonni A, Colón-Ramos DA. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development 2011, 138: 5257-5267. PMID: 22069193, PMCID: PMC3210501, DOI: 10.1242/dev.069062.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsImmunohistochemistryMicroscopy, FluorescenceNeuritesNeurogenesisPhosphatidylinositol 3-KinaseProtein IsoformsRNA InterferenceRNA, Small InterferingSignal TransductionTranscription FactorsTransgenesConceptsDAF-16/FOXOPI3KDAF-18/PTENC. elegans developmentSignal transduction cascadeNeurite outgrowthMajor negative regulatorPI3K pathway activityDaf-18Caenorhabditis elegansDAF-16Transduction cascadeFOXO pathwayNegative regulatorNeuronal cell morphologyNovel roleFOXOMammalian neuronsCorrect developmentPathway activityF isoformsNovel mechanismCell morphologyPathwayNeuronal morphology
2007
Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans
Colón-Ramos D, Margeta MA, Shen K. Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans. Science 2007, 318: 103-106. PMID: 17916735, PMCID: PMC2741089, DOI: 10.1126/science.1143762.Peer-Reviewed Original Research