2013
Sensory Neuroscience: Taste Responses in Primary Olfactory Cortex
Small DM, Veldhuizen MG, Green B. Sensory Neuroscience: Taste Responses in Primary Olfactory Cortex. Current Biology 2013, 23: r157-r159. PMID: 23428327, DOI: 10.1016/j.cub.2012.12.036.Peer-Reviewed Original Research
2012
The effect of verbal context on olfactory neural responses
Bensafi M, Croy I, Phillips N, Rouby C, Sezille C, Gerber J, Small DM, Hummel T. The effect of verbal context on olfactory neural responses. Human Brain Mapping 2012, 35: 810-818. PMID: 23225581, PMCID: PMC6869804, DOI: 10.1002/hbm.22215.Peer-Reviewed Original ResearchMidbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart S, Veldhuizen MG, Geha P, Small DM. Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger. Appetite 2012, 60: 168-174. PMID: 23064394, PMCID: PMC3526000, DOI: 10.1016/j.appet.2012.09.032.Peer-Reviewed Original ResearchConceptsAbsence of hungerFunctional magnetic resonance imagingSubsequent intakeRatings of hungerPeriaqueductal gray regionMidbrain responsesMagnetic resonance imagingKey reward regionsPalatable milkshakeSignificant positive associationPalatable foodResonance imagingInsular responsesOrbitofrontal cortexNeural circuitsGreater intakeMilkshake consumptionIntakeReward regionsBrain responsesEnhanced responseMilkshakePositive associationMidbrainGray regionFlavor is in the brain
Small DM. Flavor is in the brain. Physiology & Behavior 2012, 107: 540-552. PMID: 22542991, DOI: 10.1016/j.physbeh.2012.04.011.Peer-Reviewed Original ResearchMeSH KeywordsBrain StemCerebral CortexFood PreferencesFunctional NeuroimagingHumansIllusionsTaste PerceptionThalamus
2011
Modality-Specific Neural Effects of Selective Attention to Taste and Odor
Veldhuizen MG, Small DM. Modality-Specific Neural Effects of Selective Attention to Taste and Odor. Chemical Senses 2011, 36: 747-760. PMID: 21685407, PMCID: PMC3175104, DOI: 10.1093/chemse/bjr043.Peer-Reviewed Original ResearchConceptsPrimary olfactory cortexPrimary taste cortexAnterior insular cortexInsular cortexOlfactory cortexTaste cortexPrimary gustatory cortexFunctional magnetic resonancePrimary olfactoryGustatory cortexModality-specific activationInsular responsesNeural effectsCortexBrain responsesMultimodal regionsTaste perceptionMagnetic resonanceGeneral effectSelective attentionActivationResponse
2010
Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula
Rudenga K, Green B, Nachtigal D, Small DM. Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula. Chemical Senses 2010, 35: 693-703. PMID: 20595201, PMCID: PMC2943409, DOI: 10.1093/chemse/bjq068.Peer-Reviewed Original ResearchConceptsAnterior ventral insulaVentral insulaOral stimulationTasteless control solutionFunctional magnetic resonanceVentral pallidumPhysiological significanceHarmful stimuliInsular responsesInsulaOral sensationNutritive stimulusModalitiesDifferential connectivityPresent studyStimulationMagnetic resonanceSensory modalitiesSubjectsHypothalamusStimuliStriatumPallidumTaste representation in the human insula
Small DM. Taste representation in the human insula. Brain Structure And Function 2010, 214: 551-561. PMID: 20512366, DOI: 10.1007/s00429-010-0266-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetiteBiological EvolutionCerebral CortexFeeding BehaviorHumansMouthPrimatesSpecies SpecificityTasteVisceral AfferentsConceptsInsular cortexTaste cortexTaste representationsUnimodal sensory corticesPrimary taste cortexHuman insular cortexAnterior insular cortexHuman insulaInterspecies differencesSensory cortexSense of tasteCortexFeeding behaviorSensory regionsSignificant interspecies differencesCritical relayPrimary aimMonkeysHumans
2008
Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study
Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM. Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study. Journal Of Psychopathology And Clinical Science 2008, 117: 924-935. PMID: 19025237, PMCID: PMC2681092, DOI: 10.1037/a0013600.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAdolescent girlsGreater activationFunctional magnetic resonance imaging studySomatosensory regionsRelation of rewardGustatory cortexDopamine receptor availabilityMagnetic resonance imaging studyResonance imaging studyChocolate milkshakeTasteless solutionConsequent weight gainFood intakeBrain regionsGreater rewardsHedonic aspectsDecreased activationWeak activationRewardReceptor availabilityMilkshakeGirlsImaging studiesMagnetic resonance imagingModulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment
Bagurdes LA, Mesulam MM, Gitelman DR, Weintraub S, Small DM. Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment. Neuropsychologia 2008, 46: 2943-2948. PMID: 18602410, DOI: 10.1016/j.neuropsychologia.2008.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAnalysis of VarianceAttentionCase-Control StudiesCerebral CortexCognition DisordersDementiaDiscrimination, PsychologicalHumansLimbic SystemMagnetic Resonance ImagingMatched-Pair AnalysisMiddle AgedMotivationReaction TimeReference ValuesRewardSeverity of Illness IndexSpace PerceptionConceptsSpatial attentionSpatial attention networkAttentional shiftsMild cognitive impairmentAttention networkHealthy agingOrbitofrontal cortexCovert attention taskSelective spatial attentionCognitive impairmentUnderlying neural circuitryAD-related declineAttention taskSelective attentionEmotional contentOFC activationPCC activationSpatial cuesSecondary reinforcerInfluence of incentivesPosterior cingulateNeural circuitryNovel eventsCurrent experimentsBehavioral effects
2007
Trying to Detect Taste in a Tasteless Solution: Modulation of Early Gustatory Cortex by Attention to Taste
Veldhuizen MG, Bender G, Constable RT, Small DM. Trying to Detect Taste in a Tasteless Solution: Modulation of Early Gustatory Cortex by Attention to Taste. Chemical Senses 2007, 32: 569-581. PMID: 17495173, DOI: 10.1093/chemse/bjm025.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehaviorBrain MappingCerebral CortexDiscrimination, PsychologicalFemaleHumansMaleSolutionsStimulation, ChemicalTaste
2005
Taste and Olfactory Intensity Perception Changes Following Left Insular Stroke
Mak YE, Simmons KB, Gitelman DR, Small DM. Taste and Olfactory Intensity Perception Changes Following Left Insular Stroke. Behavioral Neuroscience 2005, 119: 1693-1700. PMID: 16420174, DOI: 10.1037/0735-7044.119.6.1693.Peer-Reviewed Original ResearchDifferential Neural Responses Evoked by Orthonasal versus Retronasal Odorant Perception in Humans
Small DM, Gerber JC, Mak YE, Hummel T. Differential Neural Responses Evoked by Orthonasal versus Retronasal Odorant Perception in Humans. Neuron 2005, 47: 593-605. PMID: 16102541, DOI: 10.1016/j.neuron.2005.07.022.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexCaudolateral orbitofrontal cortexRoute of deliveryInsula/operculumMedial orbitofrontal cortexPerigenual cingulateOral cavityCentral sulcusDifferential neural responsesRetronasal olfactionRetronasal routeBrain responsesNeural responsesNeural recruitmentDifferential activationPreferential activityCortexOdorant perceptionOrthonasalRetronasalDifferential neural recruitmentDeliveryResponseThalamusHippocampusGustatory agnosia
Small DM, Bernasconi N, Bernasconi A, Sziklas V, Jones-Gotman M. Gustatory agnosia. Neurology 2005, 64: 311-317. PMID: 15668430, DOI: 10.1212/01.wnl.0000149515.77718.35.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgnosiaAmygdalaAnorexiaAtrophyCerebral CortexElectrodes, ImplantedElectroencephalographyEpilepsy, Temporal LobeFemaleFollow-Up StudiesFood PreferencesHippocampusHumansMagnetic Resonance ImagingMeningoencephalitisNeuropsychological TestsOlfaction DisordersPositron-Emission TomographyPostoperative ComplicationsTasteTaste ThresholdTemporal LobeConceptsMedial temporal lobeTemporal lobeSurgical treatmentLeft medial temporal lobeAnteromedial temporal lobeFunctional neuroimaging studiesBilateral atrophyIntractable epilepsyComplete atrophyPreoperative MRIGustatory functionLeft amygdalaLeft insulaChemosensory evaluationNeuroimaging studiesTaste abilityPatientsAtrophyAmygdalaAversive tasteLobeRecognition thresholdAgnosiaTreatmentTaste quality
2004
Crossmodal integration – insights from the chemical senses
Small D. Crossmodal integration – insights from the chemical senses. Trends In Neurosciences 2004, 27: 120-123. PMID: 15046082, DOI: 10.1016/j.tins.2004.01.002.Peer-Reviewed Original ResearchConceptsSuperior temporal sulcusStudy of auditionMultisensory integrationNeural correlatesTemporal sulcusVisual cuesOrbitofrontal cortexAssociation cortexHuman brainCrossmodalChemical sensesCortexAuditionCuesCongruencySomatosensationSulcusSensesCorrelatesOdor detectionFacilitationUnderstandingNew studiesBrain
1999
Human cortical gustatory areas
Small D, Zald D, Jones-Gotman M, Zatorre R, Pardo J, Frey S, Petrides M. Human cortical gustatory areas. Neuroreport 1999, 10: 7-13. PMID: 10094124, DOI: 10.1097/00001756-199901180-00002.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingCerebral CortexFrontal LobeHumansMagnetic Resonance ImagingParietal LobeTasteTomography, Emission-Computed