2016
Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior
Burke MV, Small DM. Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior. Current Opinion In Behavioral Sciences 2016, 9: 97-105. PMID: 29619405, PMCID: PMC5879782, DOI: 10.1016/j.cobeha.2016.02.036.Peer-Reviewed Original ResearchFood cue reactivityCue reactivityWeight gain susceptibilityDorsal striatal dopamineEnergy-dense dietInhibitory controlModern food environmentChronic consumptionImpaired inhibitory controlStriatal dopamineStriatal functionStriatal circuitsAnimal studiesBody weightMetabolic diseasesDiet-induced adaptationsPalatable foodDense dietBrain functionIngestive behaviorFood environmentImpair inhibitory controlDietDeleterious influenceNegative outcomes
2015
Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility. Journal Of Neuroscience 2015, 35: 7964-7976. PMID: 25995480, PMCID: PMC4438134, DOI: 10.1523/jneurosci.3884-14.2015.Peer-Reviewed Original ResearchConceptsAbsence of hungerWeight changeBasolateral amygdalaLong-term weight changeLong-term weight gainWeight gain susceptibilityGustatory inputD2 receptor densityA1 allele carriersAmygdala responseSated subjectsGhrelin levelsInitial BMILateral hypothalamusHuman hypothalamusAllele carriersReceptor densityAmygdala pathwayHealthy individualsElicit eatingDopamine signalingConfer susceptibilityWeight gainDynamic causal modelingNonhomeostatic eating
2012
Orosensory and Homeostatic Functions of the Insular Taste Cortex
de Araujo IE, Geha P, Small DM. Orosensory and Homeostatic Functions of the Insular Taste Cortex. Chemosensory Perception 2012, 5: 64-79. PMID: 25485032, PMCID: PMC4254792, DOI: 10.1007/s12078-012-9117-9.Peer-Reviewed Original ResearchInsular cortexCortex functionTaste-responsive regionsWeight gain susceptibilityCentral taste pathwaysInsular taste cortexTaste cortexTaste pathwaysCurrent evidenceNeuronal responsesHomeostatic roleChemosensory inputIntegrative circuitsBrain circuitsHomeostatic functionsCurrent experimental evidenceCortexVisual stimulationIngestive behaviorNutritional statePotential roleInsular areasFunctional mapsSensory modalitiesSomatosensory