2021
Post-traumatic olfactory loss and brain response beyond olfactory cortex
Pellegrino R, Farruggia MC, Small DM, Veldhuizen MG. Post-traumatic olfactory loss and brain response beyond olfactory cortex. Scientific Reports 2021, 11: 4043. PMID: 33597627, PMCID: PMC7889874, DOI: 10.1038/s41598-021-83621-2.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexOlfactory impairmentOlfactory cortexFunctional anosmiaPost-traumatic olfactory lossPrimary olfactory areasWhole-brain responsesBrain responsesGray matter densityHigher-order areasOlfactory lossPiriform cortexHead traumaHealthy controlsOlfactory areasOdorless stimuliOlfactory functionMediodorsal thalamusCortical areasVentromedial prefrontal cortexCingulate cortexFrontal operculumCortexAnterior insulaPrefrontal cortex
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2014
The neural signature of satiation is associated with ghrelin response and triglyceride metabolism
Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiology & Behavior 2014, 136: 63-73. PMID: 24732416, PMCID: PMC4195817, DOI: 10.1016/j.physbeh.2014.04.017.Peer-Reviewed Original ResearchConceptsPalatable foodMeal terminationBrain responsesAd libitum mealPost-prandial reductionMedial orbitofrontal cortexDorsolateral prefrontal cortexGhrelin responseAcute changesFree fatty acidsPeripheral signalsTriglyceride metabolismBrain regionsBrain circuitsOrbitofrontal cortexPrefrontal cortexAmount of foodGhrelinMidbrainMilkshakeTriglyceridesCortexFatty acidsEnergy storesGreater attenuation
2005
Odor/taste integration and the perception of flavor
Small DM, Prescott J. Odor/taste integration and the perception of flavor. Experimental Brain Research 2005, 166: 345-357. PMID: 16028032, DOI: 10.1007/s00221-005-2376-9.Peer-Reviewed Original ResearchConceptsFlavor perceptionUnitary perceptionCross-modal sensory interactionsSensory inputVentral lateral prefrontal cortexParticular sensory characteristicsLateral prefrontal cortexPosterior parietal cortexMultiple sensory inputsAnterior cingulate cortexPerception of flavorAttentional allocationHeteromodal regionsNeural processesAnterior insulaFlavor processingFrontal operculumOrbitofrontal cortexPrefrontal cortexCingulate cortexFlavor of foodParietal cortexNeurophysiological studiesPerceptionSensory interaction
2004
Experience-Dependent Neural Integration of Taste and Smell in the Human Brain
Small DM, Voss J, Mak YE, Simmons KB, Parrish T, Gitelman D. Experience-Dependent Neural Integration of Taste and Smell in the Human Brain. Journal Of Neurophysiology 2004, 92: 1892-1903. PMID: 15102894, DOI: 10.1152/jn.00050.2004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexPosterior parietal cortexOrbitofrontal cortexCaudal orbitofrontal cortexFrontal operculumPrefrontal cortexParietal cortexFlavor perceptionVentral lateral prefrontal cortexVentral insulaEvent-related fMRIVentrolateral prefrontal cortexLateral prefrontal cortexDistinct sensory inputsAnterior ventral insulaPerception of flavorUnimodal stimuliSuperadditive responsesNeural correlatesBrain responsesNeural responsesFlavor processingNeural suppressionOlfactory deliveryDorsal insula
2003
The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam M. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. NeuroImage 2003, 18: 633-641. PMID: 12667840, DOI: 10.1016/s1053-8119(02)00012-5.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCue benefitPrefrontal cortexPosterior cingulateAttention-related areasNeutral cuesCentral cuesSpatial attentionSpatial expectancyFMRI scanningIrrelevant locationsMotivational valenceGreater activationParietal cortexBrain regionsCuesPeripheral targetsReaction timeCingulateCortexDistractibilityExpectancySignificant eventsAttentionValence