Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma
Rubinstein JC, Brown TC, Christison-Lagay ER, Zhang Y, Kunstman JW, Juhlin CC, Nelson-Williams C, Goh G, Quinn CE, Callender GG, Udelsman R, Lifton RP, Korah R, Carling T. Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma. BMC Cancer 2016, 16: 646. PMID: 27538953, PMCID: PMC4989347, DOI: 10.1186/s12885-016-2665-7.Peer-Reviewed Original ResearchConceptsSingle nucleotide substitutionSomatic evolutionCommon ancestor cellGenomic changesNucleotide substitutionsTissue typesTissue-specific signaturesGenomic divergenceGenomic variationGenomic instabilityGenomic signaturesRisk of tumorigenesisSelective pressurePTC tumorigenesisTumor genomesAncestor cellsGenomeA transversionMethodsExome sequencingDiverse mutationsSomatic eventsMutational spectrumT transitionNovel patternTumorigenesisDissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma
Javid M, Graham E, Malinowski J, Quinn CE, Carling T, Udelsman R, Callender GG. Dissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma. Journal Of The American College Of Surgeons 2016, 222: 1066-1073. PMID: 27049777, DOI: 10.1016/j.jamcollsurg.2016.02.006.Peer-Reviewed Original ResearchConceptsLateral neck dissectionPapillary thyroid carcinomaPositive lymph nodesNeck dissectionLymph node metastasisRadical neck dissectionThyroid carcinomaLevel IIInitial dissectionNerve injuryLymph nodesNode metastasisLateral neck lymph node metastasisTherapeutic lateral neck dissectionNeck lymph node metastasisRegional lymph node metastasisInitial neck dissectionLevel II diseaseTemporary nerve injuryLarge patient seriesPermanent nerve injuryIpsilateral lymphReoperative surgerySurgical resectionConsecutive patients