2019
Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma
Brown TC, Nicolson NG, Stenman A, Juhlin CC, Gibson CE, Callender GG, Korah R, Carling T. Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma. Journal Of The American College Of Surgeons 2019, 229: 305-315. PMID: 31034883, DOI: 10.1016/j.jamcollsurg.2019.04.018.Peer-Reviewed Original ResearchConceptsAdrenocortical carcinomaACC cell linesIGF1 overexpressionInsulin-like growth factorFunctional adrenocortical carcinomaIGF1 receptor activationRelationship of IGFWhole-exome sequencing analysisCancer Genome Atlas (TCGA) databaseEarly-stage tumorsCell linesGene amplificationCopy number variationsGrowth factor dysregulationAdrenal carcinogenesisCancer Genome AtlasExploratory cohortTumor characteristicsPolymerase chain reaction methodLarge tumorsIGF1R activationNCI-H295R.Chain reaction methodIGF treatmentQuantitative polymerase chain reaction method
2014
Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center
Quinn CE, Healy J, Lebastchi AH, Brown TC, Stein JE, Prasad ML, Callender GG, Carling T, Udelsman R. Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center. Journal Of The American College Of Surgeons 2014, 220: 1054-1062. PMID: 25488353, DOI: 10.1016/j.jamcollsurg.2014.10.007.Peer-Reviewed Original ResearchConceptsParathyroid carcinomaAtypical adenomasReferral centerParathyroid tumorsIntact parathyroid hormone levelsTertiary academic referral centerClinicopathologic tumor characteristicsParathyroid carcinoma patientsParathyroid hormone levelsAcademic referral centerAtypical parathyroid adenomaLoss of parafibrominHypercalcemic crisisProspective databaseIntraoperative variablesPathologic variablesRare malignancySurgical treatmentCarcinoma patientsClinical presentationSerum calciumTumor characteristicsParathyroid adenomaPostoperative managementTumor size