Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma
Brown TC, Nicolson NG, Stenman A, Juhlin CC, Gibson CE, Callender GG, Korah R, Carling T. Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma. Journal Of The American College Of Surgeons 2019, 229: 305-315. PMID: 31034883, DOI: 10.1016/j.jamcollsurg.2019.04.018.Peer-Reviewed Original ResearchConceptsAdrenocortical carcinomaACC cell linesIGF1 overexpressionInsulin-like growth factorFunctional adrenocortical carcinomaIGF1 receptor activationRelationship of IGFWhole-exome sequencing analysisCancer Genome Atlas (TCGA) databaseEarly-stage tumorsCell linesGene amplificationCopy number variationsGrowth factor dysregulationAdrenal carcinogenesisCancer Genome AtlasExploratory cohortTumor characteristicsPolymerase chain reaction methodLarge tumorsIGF1R activationNCI-H295R.Chain reaction methodIGF treatmentQuantitative polymerase chain reaction method