1998
The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament
Hildebrand K, Woo S, Smith D, Allen C, Deie M, Taylor B, Schmidt C. The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament. The American Journal Of Sports Medicine 1998, 26: 549-554. PMID: 9689377, DOI: 10.1177/03635465980260041401.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBecaplerminBiomechanical PhenomenaCell DivisionCollateral LigamentsDose-Response Relationship, DrugDrug CombinationsEpidermal Growth FactorExtracellular MatrixFibrin Tissue AdhesiveFibroblastsKnee InjuriesMaleMitogensPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisRabbitsRecombinant ProteinsRuptureTensile StrengthTransforming Growth Factor betaWeight-BearingWound HealingConceptsPlatelet-derived growth factor-BBMedial collateral ligament healingMedial collateral ligamentGrowth factor-BBPlatelet-derived growthCollateral ligamentGrowth factorFactor-BBLigament healingRight medial collateral ligamentFemur-medial collateral ligament-tibia complexRabbit medial collateral ligamentIndividual growth factorsHistologic evaluationHigh doseFibrin sealantControl groupHealing ligamentBiologic approachesFibroblast proliferationLigamentVitro workHealing tissueDosesHealing
1997
The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF
Deie M, Marui T, Allen C, Hildebrand K, Georgescu H, Niyibizi C, Woo S. The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF. Mechanisms Of Ageing And Development 1997, 97: 121-130. PMID: 9226631, DOI: 10.1016/s0047-6374(97)00049-3.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentEffect of ageEpidermal growth factorTotal protein synthesisMCL fibroblastsGrowth factorImmature rabbitsProtein synthesisSenescent groupCollateral ligamentTGF-β1Baseline levelsOwn controlDifferent dosesLigament fibroblastsLess collagenCollagen synthesisEGF doseRabbitsAgeSignificant reductionDoseDosesMatrix synthesisFibroblasts