2015
Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery
Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, McArthur E, Thiessen-Philbrook H, Shortt C, Shlipak M, Whitlock R, Parikh CR. Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal Of The American Society Of Nephrology 2015, 26: 3123-3132. PMID: 25855775, PMCID: PMC4657830, DOI: 10.1681/asn.2014080764.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCanadaCardiac Surgical ProceduresCreatinineFemaleFollow-Up StudiesHumansInterleukin-10Interleukin-6Lipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodPreoperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsUnited StatesConceptsIL-10 concentrationsIL-6 concentrationsPlasma IL-6IL-6IL-10Cardiac surgeryHigh riskLower riskPeak IL-6 concentrationNeutrophil gelatinase-associated lipocalinPathophysiology of AKIPostoperative IL-6Long-term mortalityGelatinase-associated lipocalinBiomarkers of inflammationRisk of mortalityDose-dependent mannerHospital AKIAKI biomarkersCause mortalityPerioperative outcomesPreoperative concentrationsSerum creatinineDL increaseSecond tertile
2008
Abstract 4574: Validation of Early Biomarkers of Acute Kidney Injury After Pediatric Cardiac Surgery
Krawczeski C, Devarajan P, Nguyen M, Kathman T, Wang Z, Parikh C. Abstract 4574: Validation of Early Biomarkers of Acute Kidney Injury After Pediatric Cardiac Surgery. Circulation 2008, 118 DOI: 10.1161/circ.118.suppl_18.s_914-a.Peer-Reviewed Original ResearchAcute kidney injuryCardiac surgerySerum creatinineKidney injuryEarly biomarkers of acute kidney injuryDuration of acute kidney injuryBiomarker of acute kidney injuryModerate acute kidney injurySeverity of acute kidney injuryPrognosis of acute kidney injuryClinical acute kidney injuryInitiation of cardiopulmonary bypassLength of hospital stayCongenital heart diseasePeak serum creatininePediatric cardiac surgeryA1MA1-acid glycoproteinClinical laboratory platformsSELDI-TOF-MSAmerican Heart AssociationDialysis requirementPediatric patientsCardiopulmonary bypassHospital stay