2015
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer
Bartel DL, Rela L, Hsieh L, Greer CA. Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer. The Journal Of Comparative Neurology 2015, 523: 1145-1161. PMID: 25420934, PMCID: PMC4390432, DOI: 10.1002/cne.23714.Peer-Reviewed Original ResearchConceptsExternal plexiform layerDendrodendritic synapsesPlexiform layerSynaptic densityOlfactory bulb projection neuronsReciprocal dendrodendritic synapsesGranule cell spinesPostsynaptic scaffolding proteinOdor informationIR punctaProjection neuronsSecondary dendritesInhibitory synapsesT cellsInhibitory inputsCell synapseGranule cellsSynaptic circuitsSynaptic propertiesCell bodiesSynapsesCurrent spreadDendritesSynapseTemporal coding
2014
Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons
Lepousez G, Nissant A, Bryant AK, Gheusi G, Greer CA, Lledo PM. Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 13984-13989. PMID: 25189772, PMCID: PMC4183341, DOI: 10.1073/pnas.1404991111.Peer-Reviewed Original ResearchConceptsAdult-born granule cellsAdult-born neuronsInput-specific synaptic plasticityOlfactory bulbGranule cellsOlfactory cortexSynaptic plasticityOptogenetic stimulationOlfactory learningSelective optogenetic stimulationOlfactory information processingCircuit remodelingCortical projectionsSpine densityAdult neurogenesisOB neuronsNew neuronsExcitatory inputsInhibitory inputsSynaptic mechanismsDendritic portionsDendritic treeNeuronsFunctional plasticityElectrophysiological analysis
2010
Age-induced disruption of selective olfactory bulb synaptic circuits
Richard MB, Taylor SR, Greer CA. Age-induced disruption of selective olfactory bulb synaptic circuits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 15613-15618. PMID: 20679234, PMCID: PMC2932573, DOI: 10.1073/pnas.1007931107.Peer-Reviewed Original ResearchConceptsMouse OBLayer-specific alterationsAfferent synaptic inputExternal plexiform layerPrimary sensory cortexAge-related alterationsAge-related cognitive deficitsNeuronal lossOlfactory bulb circuitryProjection neuronsPlexiform layerOB glomeruliQuantitative morphometric analysisSynaptic densityGlomerular layerInterneuron subpopulationsOlfactory functionOSN axonsSynaptic inputsSensory cortexOB layersSynaptic circuitsSensory functionOB circuitryCognitive deficits
2009
Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB
Imamura F, Greer CA. Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB. PLOS ONE 2009, 4: e6729. PMID: 19707543, PMCID: PMC2727791, DOI: 10.1371/journal.pone.0006729.Peer-Reviewed Original ResearchConceptsMitral/TrkB activationOlfactory bulbApical dendritesDendritic developmentLateral dendriteDendritic branchingExternal plexiform layerReciprocal dendrodendritic synapsesEarly postnatal daysOlfactory bulb mitralTrkB neurotrophin receptorMammalian olfactory bulbSame odor receptorOlfactory sensory neuronsTufted CellsDendrodendritic synapsesTrkB receptorsDendritic differentiationOB neuronsProjection neuronsPlexiform layerNeurotrophin receptorPostnatal daySensory neurons
2007
Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits
Whitman MC, Greer CA. Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits. Journal Of Neuroscience 2007, 27: 9951-9961. PMID: 17855609, PMCID: PMC6672649, DOI: 10.1523/jneurosci.1633-07.2007.Peer-Reviewed Original ResearchConceptsExternal plexiform layerGranule cell layerAdult-generated granule cellsGranule cellsOlfactory bulbSynaptic integrationLocal circuitsOlfactory bulb granule cellsNew granule cellsSubventricular zone migrateAdult mammalian olfactory bulbMammalian olfactory bulbElaborate dendritic arborsBasal dendritesPostsynaptic markersAxon collateralsSynaptic markersPlexiform layerPeriglomerular cellsDendritic arborsMitral/Spine increasesDendritic spinesNew interneuronsD postinfection