2023
Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinence
2020
A feasibility study providing substance use treatment in the Black church
Jordan A, Babuscio T, Nich C, Carroll KM. A feasibility study providing substance use treatment in the Black church. Journal Of Substance Use And Addiction Treatment 2020, 124: 108218. PMID: 33771290, DOI: 10.1016/j.jsat.2020.108218.Peer-Reviewed Original ResearchConceptsTechnology-based treatmentsClinical trialsSUD treatmentBlack adultsNonrandomized feasibility studyUrine toxicology screenHealth care disparitiesEvidence-based interventionsDSM-5 criteriaAdequate numberCognitive behavioral therapyDisseminable strategyUndertreated populationToxicology screenCurrent SUDCare disparitiesHealth advisorsBehavioral therapySubstance useMean numberTreatmentHigh uptakeFeasibility studyCBT4CBTTrials
2018
Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder
Carroll KM, Nich C, Frankforter TL, Yip SW, Kiluk BD, DeVito EE, Sofuoglu M. Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder. Drug And Alcohol Dependence 2018, 192: 264-270. PMID: 30300800, PMCID: PMC6203294, DOI: 10.1016/j.drugalcdep.2018.08.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderOral naltrexoneUse disordersAffective symptomsVoucher-based contingency managementDysphoric symptomsAffective distressOral naltrexone treatmentMultiple baseline characteristicsBaseline characteristicsNaltrexone treatmentHigh riskNaltrexoneSomatic symptomsSymptomsContingency managementTreatmentHigh rateDistressSubstantial evidenceTrialsTheoretical benefitsDisordersAffective discomfortParticipantsCulturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisorders
2016
Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence
Decker SE, Kiluk BD, Frankforter T, Babuscio T, Nich C, Carroll KM. Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence. Journal Of Consulting And Clinical Psychology 2016, 84: 907-912. PMID: 27454780, PMCID: PMC5341374, DOI: 10.1037/ccp0000126.Peer-Reviewed Original ResearchConceptsUrine toxicology screenCognitive behavioral therapyCocaine use outcomesHomework adherenceTreatment attendanceToxicology screenCocaine useUse outcomesMultiple logistic regressionBaseline cocaine useVariety of disordersCocaine use severityTreatment endClinical trialsCocaine use frequencyImproved outcomesCocaine dependenceLogistic regressionCBT sessionsAdherenceUse severityPrior studiesGreater reductionOutcomesTreatment
2011
Utilizing Peer Mentorship to Engage High Recidivism Substance-Abusing Patients in Treatment
Tracy K, Burton M, Nich C, Rounsaville B. Utilizing Peer Mentorship to Engage High Recidivism Substance-Abusing Patients in Treatment. The American Journal Of Drug And Alcohol Abuse 2011, 37: 525-531. PMID: 21851202, DOI: 10.3109/00952990.2011.600385.Peer-Reviewed Original ResearchConceptsSubstance-using patientsSubstance abuse patientsSubstance use disordersPrimary outcomeOutpatient treatmentOutpatient appointmentsLack of attendanceTreatment appointmentsHospital settingPast diagnosisUse disordersTreatment attendanceSubstance abusePatientsTreatmentHigh recidivismPeer mentorshipTauAddiction problemsAppointmentsAttendanceMindfulness training for smoking cessation: Results from a randomized controlled trial
Brewer JA, Mallik S, Babuscio TA, Nich C, Johnson HE, Deleone CM, Minnix-Cotton CA, Byrne SA, Kober H, Weinstein AJ, Carroll KM, Rounsaville BJ. Mindfulness training for smoking cessation: Results from a randomized controlled trial. Drug And Alcohol Dependence 2011, 119: 72-80. PMID: 21723049, PMCID: PMC3191261, DOI: 10.1016/j.drugalcdep.2011.05.027.Peer-Reviewed Original ResearchConceptsAbstinence ratesPoint prevalence abstinence ratesLong-term abstinence ratesCigarettes/dayCurrent standard treatmentEnd of treatmentPoint prevalence abstinenceAmerican Lung Association's FreedomMindfulness trainingPrimary outcomeCigarette smokingSmoking cessationStandard treatmentClinical trialsWeek 17Preventable deathsPsychiatric disordersSmoking treatmentCigarette useNicotine-dependent adultsTrialsCessationGroup formatTreatmentInitial trial
2010
Informal discussions in substance abuse treatment sessions with Spanish-speaking clients
Bamatter W, Carroll KM, Añez LM, Paris M, Ball SA, Nich C, Frankforter TL, Suarez-Morales L, Szapocznik J, Martino S. Informal discussions in substance abuse treatment sessions with Spanish-speaking clients. Journal Of Substance Use And Addiction Treatment 2010, 39: 353-363. PMID: 20817381, PMCID: PMC2967664, DOI: 10.1016/j.jsat.2010.07.005.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapyStandard treatmentDrug Abuse Clinical Trials Network protocolTreatment sessionsSubstance abuse treatment outcomesSignificant inverse correlationHispanic clientsEarly treatment sessionsSession audiotapesTreatment outcomesSubstance abuse treatment sessionsEnhancement therapyClient motivationSubstance useInverse correlationTreatment fidelityNational InstituteTreatmentAdverse consequencesTrialsSessionsClient retentionMonolingual SpanishTeaching community program clinicians motivational interviewing using expert and train‐the‐trainer strategies
Martino S, Ball SA, Nich C, Canning‐Ball M, Rounsaville BJ, Carroll KM. Teaching community program clinicians motivational interviewing using expert and train‐the‐trainer strategies. Addiction 2010, 106: 428-441. PMID: 20925684, PMCID: PMC3017235, DOI: 10.1111/j.1360-0443.2010.03135.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultClinical CompetenceConnecticutEducation, Medical, ContinuingEducational MeasurementFemaleHumansInterview, PsychologicalMaleMiddle AgedMotivationProgram DevelopmentProgram EvaluationRegression AnalysisSubstance Abuse Treatment CentersSubstance-Related DisordersTeachingTeaching MaterialsTechnology TransferConceptsClinical trial standardsTreatment programPercentage of cliniciansMental health treatment programsCommunity treatment programsMI adherencePrimary outcomeClinician adherenceProgram cliniciansMI performanceTrainer strategyCliniciansAddiction treatmentTrial standardsTrainer approachAdherenceTT conditionsHigh percentageTreatmentSkill-building workshopsTTExMIEffective strategyStudyQuality versus quantity: acquisition of coping skills following computerized cognitive–behavioral therapy for substance use disorders
Kiluk BD, Nich C, Babuscio T, Carroll KM. Quality versus quantity: acquisition of coping skills following computerized cognitive–behavioral therapy for substance use disorders. Addiction 2010, 105: 2120-2127. PMID: 20854334, PMCID: PMC2975828, DOI: 10.1111/j.1360-0443.2010.03076.x.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized CBT programEffects of CBTComputerized cognitive behavioral therapySubstance use disordersEffect of treatmentSubstance use outcomesRole-play taskTreatment completionHigh riskPrimary drugUse disordersAverage ageCommunity settingsBehavioral therapyPatient treatmentSubstance dependenceAlcohol useCBT programSubstance useUse outcomesComputerized versionParticipants' durationSignificant increaseTreatment
2009
Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study
Brewer JA, Sinha R, Chen JA, Michalsen RN, Babuscio TA, Nich C, Grier A, Bergquist KL, Reis DL, Potenza MN, Carroll KM, Rounsaville BJ. Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study. Substance Use & Addiction Journal 2009, 30: 306-317. PMID: 19904666, PMCID: PMC3045038, DOI: 10.1080/08897070903250241.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive behavioral therapyUse disordersDrug useStress reactivityMindfulness trainingCocaine use disorderTreatment satisfactionOutpatient settingStage IStress provocationBehavioral therapySubstance abuseTreatment acceptabilityPilot studySubstance useTreatmentDisordersProvocationPhysiological indicesRandomizedTherapyStudyIndividualsWeekly
2008
Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT
Carroll KM, Ball SA, Martino S, Nich C, Babuscio TA, Rounsaville BJ. Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT. Drug And Alcohol Dependence 2008, 100: 178-181. PMID: 19041197, PMCID: PMC2742309, DOI: 10.1016/j.drugalcdep.2008.09.015.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyComputer-assisted training programSubstance dependenceComputer-based trainingSubstance use outcomesComputer-assisted versionDrug useEnduring effectCBT4CBTUse outcomesRandomized clinical trialsTreatment retentionDurability of effectTraining programOutpatient communityStudy treatmentStandard treatmentOutpatient treatmentClinical trialsTreatment conditionsParticipantsSignificant differencesTreatmentRegression analysisWhat is usual about “treatment-as-usual”? Data from two multisite effectiveness trials
Santa Ana EJ, Martino S, Ball SA, Nich C, Frankforter TL, Carroll KM. What is usual about “treatment-as-usual”? Data from two multisite effectiveness trials. Journal Of Substance Use And Addiction Treatment 2008, 35: 369-379. PMID: 18337053, PMCID: PMC2712113, DOI: 10.1016/j.jsat.2008.01.003.Peer-Reviewed Original ResearchConceptsEffectiveness trialDrug Abuse Clinical Trials NetworkSubstance useMultisite effectiveness trialClinical Trials NetworkStandard clinical practiceParticipants' substance useCommunity-based drug abuse treatmentDrug abuse treatmentNumber of interventionsSubstance use outcomesPatient outcomesClinical practiceTrials NetworkAbuse treatmentUse outcomesNational InstituteSocial functioningTreatmentTrialsOpen-ended questionsOutcomesStandard practiceEarly stagesEarly sessions
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential responseCost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients
Jofre-Bonet M, Sindelar JL, Petrakis IL, Nich C, Frankforter T, Rounsaville BJ, Carroll KM. Cost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients. Journal Of Substance Use And Addiction Treatment 2004, 26: 225-232. PMID: 15063917, PMCID: PMC3662046, DOI: 10.1016/s0740-5472(04)00004-2.Peer-Reviewed Original ResearchConceptsMethadone treatmentClinical trialsCocaine useDouble-blind clinical trialCocaine dependenceStandard methadone treatmentBlind clinical trialMethadone-maintained patientsRandomized clinical trialsOpioid-dependent subjectsMethadone-maintained opiate addictsStandard treatmentOutcome measuresOpioid addictsPromising treatmentOpiate addictsIncremental costDisulfiramAdditional treatmentNumber of daysTrialsTreatmentCost effectivenessEconomic evaluationAddictsPrize reinforcement contingency management for treating cocaine users: how low can we go, and with whom?
Petry NM, Tedford J, Austin M, Nich C, Carroll KM, Rounsaville BJ. Prize reinforcement contingency management for treating cocaine users: how low can we go, and with whom? Addiction 2004, 99: 349-360. PMID: 14982548, PMCID: PMC3709247, DOI: 10.1111/j.1360-0443.2003.00642.x.Peer-Reviewed Original ResearchConceptsStandard treatmentUrinalysis resultsNegative urinalysis resultsCM conditionCommunity-based treatment centersPositive urinalysis resultsCommunity-based settingsContingency management interventionSevere patientsNegative urine samplesTreatment periodCM interventionPatientsTreatment centersMore abstinenceDrug useCocaine useTreatment assignmentBeneficial effectsUrine samplesCocaine usersContingency managementTreatmentInterventionGoal-related activities
2002
‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levelsContingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude
Carroll KM, Sinha R, Nich C, Babuscio T, Rounsaville BJ. Contingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude. Experimental And Clinical Psychopharmacology 2002, 10: 54-63. PMID: 11866252, DOI: 10.1037/1064-1297.10.1.54.Peer-Reviewed Original ResearchConceptsNaltrexone treatmentContingency managementOpioid-dependent individualsSignificant reductionReinforcement magnitudeOpioid useAvailable pharmacotherapiesNaltrexone maintenanceOpioid dependenceClinical trialsCM groupBehavioral therapyNaltrexoneTreatmentCM conditionRelative benefitsParticipantsPharmacotherapyTherapyTrialsWeeks
2001
Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement
Carroll KM, Ball SA, Nich C, O'Connor PG, Eagan DA, Frankforter TL, Triffleman EG, Shi J, Rounsaville BJ. Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement. JAMA Psychiatry 2001, 58: 755-761. PMID: 11483141, PMCID: PMC3651594, DOI: 10.1001/archpsyc.58.8.755.Peer-Reviewed Original ResearchConceptsDrug-free urine specimensNaltrexone treatmentFamily counseling sessionsContingency managementOpioid dependenceTreatment retentionUrine specimensBehavioral therapyOpioid-dependent individualsCounseling sessionsDrug use outcomesSubstance abuse outcomesNaltrexone complianceNaltrexone therapyOpioid useAvailable pharmacotherapiesMedication complianceSpecific pharmacotherapySignificant improvementTherapyUse outcomesAbuse outcomesPrincipal outcomePharmacotherapyTreatmentFOCUS ON THERAPEUTIC ALLIANCE: THE PSYCHOMETRIC PROPERTIES OF SIX MEASURES ACROSS THREE TREATMENTS
Cecero J, Fenton L, Nich C, Frankforter T, Carroll K. FOCUS ON THERAPEUTIC ALLIANCE: THE PSYCHOMETRIC PROPERTIES OF SIX MEASURES ACROSS THREE TREATMENTS. Psychotherapy 2001, 38: 1-11. DOI: 10.1037/0033-3204.38.1.1.Peer-Reviewed Original Research